Knoedler, Leonard and Herfeld, Konstantin and Schaefer, Daniel A. and Diatta, Fortunay and Clune, James and Evans, Brogan and Seu, Michelle and Kim, Bong-Sung and Alfertshofer, Michael and Schaschinger, Thomas and Iske, Jasper and Knoedler, Samuel and Lellouch, Alexandre G. and Jeljeli, Maxime and Carturan, Alberto and Ruella, Marco and Heiland, Max and Poeck, Hendrik and Perl, Markus and Pomahac, Bohdan and Kauke-Navarro, Martin (2025) CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review. CELL REPORTS MEDICINE, 6 (8): 102240. ISSN 2666-3791
Full text not available from this repository. (Request a copy)Abstract
This review addresses the integration of chimeric antigen receptor (CAR)-T cell therapy with reconstructive oncologic surgery in treating peripheral solid tumors, including melanoma, sarcomas, breast cancer, and head and neck cancers. While CAR-T cells have demonstrated effectiveness in blood cancers, their efficacy in solid tumors has been limited due to tumor heterogeneity, immune suppression, and poor cellular infiltration. Emerging approaches involving localized CAR-T cell delivery, improved CAR design, and targeted antigen selection (such as HER2, MUC1, GD2, and B7-H3) are discussed as promising strategies to enhance therapeutic outcomes. Clinical studies highlighted in this review indicate improved local tumor control and potential to optimize surgical resections. Additionally, combining CAR-T therapy with surgery may reduce tumor recurrence and positively influence reconstructive outcomes. Overall, this review underscores CAR-T cell therapy as a potential adjunctive treatment in oncologic surgery, emphasizing the importance of interdisciplinary approaches to improve patient outcomes in solid tumor management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VIVO; HEAD; HER2; IMMUNOTHERAPY; EXPRESSION; DELIVERY; HYPOXIA; CARCINOMA; RESECTION; TARGET |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2026 07:36 |
| Last Modified: | 13 Oct 2026 07:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67595 |
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