Stoshikj, Slagjana and Biener, Leonie and Renner, Andreas and Bal, Christina and Brugger, Jonas and Krall, Christoph and Milger, Katrin and Schulz, Christian and Jandl, Margret and Ehmann, Rainer and Schmidt, Olaf and Buhl, Roland and Hamelmann, Eckard and Taube, Christian and Korn, Stephanie and Skowasch, Dirk and Idzko, Marco (2025) Impact of Smoking on Biological Treatment Response in Patients From the German Severe Asthma (GAN) Registry. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 13 (5). ISSN 2213-2198, 2213-2201
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BACKGROUND: Clinical studies of biologics in severe asthma exclude smokers or ex-smokers (ExS) with over 10 pack-years (py). Thus, the effectiveness of this therapy in ExS with severe asthma is not well understood. OBJECTIVES: To assess the impact of smoking on clinical efficiency of biologics in patients with severe asthma from the German Asthma Net, a comprehensive international registry. METHODS: This analysis included 1129 patients (55.8% female, mean age: 53.82-14.67 years), of whom 56% were never-smokers (NS), whereas 44% were ExS (<10 py: 22.9%, 10-20 py: 10.3%, and >20 py: 10.6%). They received benralizumab (38.3%), dupilumab (28.9%), mepolizumab (18.3%), omalizumab (14%), or reslizumab (0.5%). RESULTS: Biologic therapy significantly improved asthma control, measured by change in Asthma Control Test, Asthma Control Questionnaire-5, and Mini-Asthma Quality of Life Questionnaire, lung function, reduced exacerbations, and daily oral prednisolone dose in all patients at week 52. Of note, no significant differences in asthma control between NS and ExS at week 52 (P = .48, .09, and .15, respectively) were observed. Also, lung function improvement (forced expiratory volume in 1 second, forced vital capacity, total lung capacity, peak expiratory flow, mean expiratory flow at 50%, P > .05), and reduction in acute exacerbation (P = .8) and oral corticosteroid doses (P = .15) were comparable in NS and ExS. Markers of type 2 inflammation, such as fraction of exhaled nitric oxide and blood eosinophils, decreased in ExS similar to NS (P = .29 and P = .48, respectively). CONCLUSION: ExS with severe asthma experienced similar improvements in asthma control, exacerbations, lung function, and biomarkers as NS after 1 year of biologics, suggesting that severe asthmatics even with a substantial smoking history can benefit from biologic therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MONOCLONAL-ANTIBODY; DOUBLE-BLIND; IGE; MULTICENTER; CESSATION; ATOPY; Severe asthma; Registry; Smoking; Pack-years; Bi-ologics; Asthma control; Lung function; Biomarkers; Exacerbations |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2026 09:17 |
| Last Modified: | 23 Apr 2026 09:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67599 |
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