von Bubnoff, Dagmar and Schmitt, Christina and Goldinger, Simone M. and Schadendorf, Dirk and Kaehler, Katharina C. and Hafner, Christian and Kramer, Nora and Froehlich, Waltraud and Dummer, Reinhard and Berking, Carola and Schliep, Stefan and Kirchberger, Michael C. and Heinzerling, Lucie (2025) Prognostic and predictive value of IDO expression in metastatic melanoma treated with Ipilimumab. PLOS ONE, 20 (5): e0321937. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Background The tumor microenvironment is crucial for prognosis and response to immunotherapy in several tumor entities.Methods In a multicenter retrospective study, a total of 86 tumor samples from patients with metastatic melanoma were evaluated for baseline expression of indoleamine 2,3-dioxygenase (IDO) and programmed death ligand 1 (PD-L1). Expression patterns of IDO and PD-L1 on tumor cells and antigen-presenting cells (APCs) as determined by immunohistochemical (IHC) staining of paraffin-embedded tissue sections were correlated with response to ipilimumab and overall survival (OS). Statistical analysis was performed using the Spearman correlation, the Mann-Whitney test and Kaplan-Meier estimator.Results IDO expression in tumor cells or APCs was not predictive for treatment response. The median OS was 26 months in IDO-positive and IDO-negative patients, regardless of IDO expression in tumor cells or APCs. A correlation of IHC expression scores of IDO and PD-L1 could not be documented.Conclusion The exact role of IDO in creating an immunosuppressive tumor environment and its reversal needs to be further elucidated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; REGULATORY T-CELLS; PD-L1 EXPRESSION; DENDRITIC CELLS; LYMPH-NODES; PHASE-I; IMMUNE; INHIBITION; IMMUNOTHERAPY; RESISTANCE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2026 09:25 |
| Last Modified: | 23 Apr 2026 09:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67603 |
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