Galas, Kristin and Gleitsmann, Moritz and Rey, Julia and Solbach, Christine and Witzel, Isabell and Karn, Thomas and Schmatloch, Sabine and Schem, Christian and Schneeweis, Andreas and Sinn, Bruno and Fehm, Tanja and Denkert, Carsten and Fasching, Peter and Litmeyer, Anne-Sophie and Marme, Frederik and Jank, Paul and Mueller, Volkmar and Seiler, Sabine and Stickeler, Elmar and Ortmann, Olaf and van Mackelenbergh, Marion and Nekljudova, Valentina and Holtschmidt, Johannes and Loibl, Sibylle (2025) Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification. NPJ BREAST CANCER, 11 (1): 43. ISSN , 2374-4677
Full text not available from this repository. (Request a copy)Abstract
Breast cancer diagnosed during pregnancy (PrBC) is a rare occurrence but may become more prevalent as women nowadays tend to postpone childbearing until later in life. Further understanding of how pregnancy affects the tumor microenvironment (TME) is essential. We constructed Tissue Microarrays (TMA) of tumor specimens from 126 pregnant breast cancer (BC) patients and examined standard BC markers such as ER, PR, Ki67, HER2, tumor infiltrating lymphocytes (TILs), and immunomarkers HLA class I, HLA-G, PD-L1, TIGIT and Nectin-4. Subsequently, we compared our findings with those from a matched non-pregnant cohort of young BC patients. Pregnant BC patients were younger, had significantly higher proliferation rates and a higher expression of Nectin-4. Higher pregnancy related estrogen levels may boost proliferation und Nectin-4 overexpression, promoting BC progression. No further evidence supporting impaired maternal anti-tumor response in BC was observed in this study.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-INFILTRATING LYMPHOCYTES; ESTROGEN; RECEPTOR; CELLS; EXPRESSION; NECTIN-4; RISK; KI67; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2026 05:40 |
| Last Modified: | 20 Apr 2026 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67654 |
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