Alkemade, Joris A. and Hawkins, Nichola J. and Baraldi, Elena and Buddie, Alan G. and Cockerton, Helen M. and Corkley, Isabel and Fraaije, Bart A. and Gaya, Ester and Gifford, Danna R. and Hartig, Florian and Kanyuka, Kostya and Koch, Aline and Sanchez, Jonatan Nino and Preston, Gail M. and Seidl, Michael F. and Spanu, Pietro D. and Werner, Bernhard T. and Lyu, Joy and Barraclough, Timothy G. (2025) Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens. FUNGAL BIOLOGY REVIEWS, 53: 100443. ISSN 1749-4613, 1878-0253
Full text not available from this repository. (Request a copy)Abstract
Crop protection against fungal pathogens is essential to prevent crop losses and maintain food security. Current crop protection relies heavily on chemical fungicides. However, rapid evolution of fungicide resistance, the constant appearance of new pathogens, and legislation against chemical pesticides due to concerns regarding their impact on human health and the environment, mean new crop protection strategies are urgently required. One elegant solution is double-stranded RNA-based crop protection, which aims to silence selected genes in the pathogen to reduce crop damage. This technology brings the promise of targeting specific genes, which could be chosen to maximise protection, minimize off-target effects and reduce the risk of resistance evolution. Here we discuss strategies for successful use of this novel technology based on lessons learned from fungicide resistance and recent discoveries in fungal evolution derived from genome-sequencing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEXT-GENERATION; PLANT-PATHOGENS; FOOD SECURITY; CHALLENGES; EMERGENCE; DSRNA; RNAi; Crop protection; Fungicide resistance; Fungal pathogens; Evolutionary genomics |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Group Theoretical Ecology (Prof. Dr. Florian Hartig) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2026 09:41 |
| Last Modified: | 17 Apr 2026 09:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67683 |
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