Tadepalli, Sirimuvva and Clements, Derek R. and Raquer-McKay, Hayley M. and Ludtke, Anja and Saravanan, Sanjana and Seong, David and Vitek, Lorraine and Richards, Christopher M. and Carette, Jan E. and Mack, Matthias and Gottfried-Blackmore, Andres and Graves, Edward E. and Idoyaga, Juliana (2025) CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy. JOURNAL OF EXPERIMENTAL MEDICINE, 222 (6): e20231717. ISSN 0022-1007, 1540-9538
Full text not available from this repository. (Request a copy)Abstract
Monocytes infiltrating tumors acquire various states that distinctly impact cancer treatment. Here, we show that resistance of tumors to radiotherapy (RT) is controlled by the accumulation of monocyte-derived dendritic cells (moDCs). These moDCs are characterized by the expression of CD301b and have a superior capacity to generate regulatory T cells (Tregs). Accordingly, moDC depletion limits Treg generation and improves the therapeutic outcome of RT. Mechanistically, we demonstrate that granulocyte-macrophage colony-stimulating factor (GM-CSF) derived from radioresistant tumor cells following RT is necessary for the accumulation of moDCs. Our results unravel the immunosuppressive function of moDCs and identify GM-CSF as an immunotherapeutic target during RT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; REGULATORY T-CELLS; INFILTRATING MYELOID CELLS; GM-CSF; ANTITUMOR IMMUNITY; SUPPRESSOR-CELLS; TUMOR-CELLS; RESPONSES; VACCINATION; MACROPHAGES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2026 09:03 |
| Last Modified: | 17 Apr 2026 09:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67727 |
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