Hoffmann, Ada and Cornely, Oliver A. and Vonhoegen, Jana and Sprute, Rosanne and Reinhold, Ilana and Walther, Grit and Fuchs, Frieder and Simon, Michaela (2025) In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species. MYCOSES, 68 (11): e70131. ISSN 0933-7407, 1439-0507
Full text not available from this repository. (Request a copy)Abstract
Background Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc.Objectives As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against Nitroxoline using broth microdilution.Methods Overall, 13 Aspergillus isolates were tested according to the EUCAST guidance document (Guinea et al. EUCAST, def. doc. 9.4, 2022) including two genetically proven Azole-resistant strains.Results The overall Minimal Inhibitory Concentration (MIC)50/90 was 0.5 mg/L.Conclusions These results correspond to excellent in vitro activity against Aspergillus spp.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AZOLE RESISTANCE; SPECTRUM; Aspergillus; azole-resistance; drug repurposing; Nitroxoline |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2026 08:18 |
| Last Modified: | 01 Apr 2026 08:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67778 |
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