Wach, Johannes and Basaran, Alim Emre and Alhalabi, Obada T. and Beck, Jurgen and Butenschoen, Vicki M. and Chang, Steven D. and Czabanka, Marcus and Czernicki, Tomasz and Dammann, Philipp and Doria-Medina, Roberto and Eicker, Sven Oliver and Barrantes-Freer, Alonso and Gizaw, Christine and Guresir, Erdem and Hohenhaus, Marc and Hohenhaus, Romina and Kattaa, Ahed H. and Kilinc, Fatma and Klein, Lukas and Kogl, Nikolaus and Krieg, Sandro and Kunert, Przemyslaw and Middelkamp, Maximilian and Meyer, Bernhard and Neidert, Nicolas and Onken, Julia and Pantel, Tobias and Park, David J. and Rauschenbach, Laurel and Sankowski, Roman and Santos, Alejandro N. and Schmidt, Nils Ole and Siller, Sebastian and Sure, Ulrich and Thome, Claudius and Tihan, Tarik and Vychopen, Martin and Vajkoczy, Peter and Wostrack, Maria and Klingler, Jan-Helge (2025) Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 14 (1): 18. ISSN 2051-5960,
Full text not available from this repository. (Request a copy)Abstract
Spinal hemangioblastomas (sHB) are rare vascular tumors, with distinct clinical courses between von Hippel-Lindau (VHL)-associated and sporadic cases. The MIB-1 labeling index has been proposed as a surrogate marker for tumor proliferation, but its prognostic value remains unclear in this context. In this subgroup analysis from a multicenter retrospective study, we analyzed 116 primary sHB patients with available MIB-1 indices. Patients were stratified by VHL status. Statistical comparisons included ROC analyses for local progression-free survival (PFS) prediction and Kaplan-Meier survival curves for local PFS, stratified by a MIB-1 index cut-off derived from Youden's index. The MIB-1 index was significantly lower in VHL-associated tumors compared to sporadic ones (mean 2.17% vs. 3.02%, p = 0.008). In VHL-associated sHB, a higher MIB-1 index (>= 2%) correlated with an increased risk of local tumor progression (AUC 0.74, 95% CI 0.49-0.98), whereas this was not observed in sporadic cases (AUC 0.56, 95% CI 0.23-0.88). Kaplan-Meier analysis showed that VHL patients with MIB-1 >= 2% had significantly shorter PFS (p = 0.05), while no significant association was found in sporadic tumors (p = 0.87). Our findings suggest that while VHL-associated sHB exhibit lower proliferative indices overall, elevated MIB-1 labeling indices might serve as a prognostic marker of shorter local PFS in this subgroup. In contrast, MIB-1 index appears to have limited prognostic relevance in sporadic sHB. These results highlight the importance of further molecular stratification and proliferation assessment in sHB to better inform clinical decision-making.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROLIFERATION INDEX; EXPRESSION; Spinal hemangioblastoma; Von Hippel-Lindau disease; Local tumor progression; MIB-1 index; Progression-free survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2026 07:13 |
| Last Modified: | 31 Mar 2026 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67878 |
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