Kumowski, Nina and Pabel, Steffen and Grune, Jana and Momin, Noor and Ninh, Van K. and Stengel, Laura and Mentkowski, Kyle I. and Iwamoto, Yoshiko and Zheng, Yi and Lee, I-Hsiu and Matthias, Jessica and Wirth, Jan O. and Pulous, Fadi E. and Seung, Hana and Paccalet, Alexandre and Muse, Charlotte G. and Ting, Kenneth K. Y. and Delgado, Paul and Lewis, Andrew J. M. and Kaushal, Vaishali and Kreso, Antonia and Brown, Dennis and Hayat, Sikander and Kramann, Rafael and Swirski, Filip K. and Naxerova, Kamila and Propheter, Daniel C. and Hooper, Lora V. and Moskowitz, Michael A. and King, Kevin R. and Rosenthal, Nadia and Hulsmans, Maarten and Nahrendorf, Matthias (2025) Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia. SCIENCE, 389 (6764). pp. 1043-1048. ISSN 0036-8075, 1095-9203
Full text not available from this repository. (Request a copy)Abstract
Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrhythmias. Comparing neutrophils with macrophages, we found that resistin-like molecule gamma (Retnlg or RELM gamma) was the most differentially expressed gene in mouse infarcts. RELM gamma is part of a pore-forming protein family that defends the host against bacteria by perforating their membranes. In mice with acute infarcts, leukocyte-specific Retnlg deletion reduced ventricular tachycardia. RELM gamma elicited membrane defects that allowed cell exclusion dyes to enter the cardiomyocyte interior and also caused delayed afterdepolarizations and later cardiomyocyte death, both of which are strong arrhythmogenic triggers. Human resistin likewise attacked membranes of liposomes and mammalian cells. We describe how misdirected innate immune defense produces membrane leaks and ventricular arrhythmia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE CORONARY SYNDROME; MYOCARDIAL-ISCHEMIA; SINGLE-CELL; BORDER ZONE; MACROPHAGES; ARRHYTHMIA; REPERFUSION; NEUTROPHILS; MECHANISMS; INFARCTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Mar 2026 08:14 |
| Last Modified: | 27 Mar 2026 08:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67937 |
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