Zant, R. and Melter, M. and Schlitt, H. J. and Loss, M. and Ameres, M. and Knoppke, B. and Kunkel, J. (2014) High Levels of Procalcitonin in the Early Phase after Pediatric Liver Transplantation Indicate Poor Postoperative Outcome. HEPATO-GASTROENTEROLOGY, 61 (133). pp. 1344-1349. ISSN 0172-6390,
Full text not available from this repository. (Request a copy)Abstract
Background/Aims: To date, no data is available about procalcitonin (PCT) levels and its relevance to morbidity and graft function in the early phase after pediatric liver transplantation (pLTx). The aim of this study was to analyse the prognostic relevance of earlypostoperative PCT elevations in pediatric liver recipients. Methodology: Thirty pediatric patients who underwent 32 liver transplantations were included into this observational single-center study. Results: Patients with high PCT levels on postoperative day (POD) 2 had higher International Normalized Ratio values on POD 5 (p<0.05) and suffered more often from primary graft non-function (p<0.05). They also had a longer stay in the pediatric in-tensivecare unit (p<0.01) and on mechanical ventilation, (p=0.001). There was no correlation between PCT elevaltion and systemic infection. However, PCT levels were correlated with peak serum lactate levels immediately after graft reperfusion and elevation of serum amind-transferases on POD 1 (r2=0.61, p<0.001). Conclusion; High levels of PCT after pLTx are an early indicator of poor postoperative outcome and may reflect ischemia induced liver cell injury within the context of an isch'emia-reperfusion injury
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INJURY; INTERLEUKIN-6; ISCHEMIA; KINETICS; Procalcitonin; liver transplantation; pediatric liver transplantation; ischemia-reperfusion injury |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2019 12:42 |
| Last Modified: | 12 Sep 2019 12:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9911 |
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