Items where Author is "Elz, Sigurd"

Article

Sellmer, Andreas and Able, Marina and Spiekermann, Karsten and Reinecke, Maria and Kuster, Bernhard and Utpatel, Kirsten and Wirth, Lukas and Pongratz, Herwig and Plank, Nicole and Koch, Pierre and Elz, Sigurd and Fischer, Amrei and Tizazu, Belay and Fiebig, Heinz-Herbert and Dove, Stefan and Mahboobi, Siavosh (2025) Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296: 117849. ISSN 0223-5234, 1768-3254

Szczepanska, Katarzyna and Pockes, Steffen and Podlewska, Sabina and Horing, Carina and Mika, Kamil and Latacz, Gniewomir and Bednarski, Marek and Siwek, Agata and Karcz, Tadeusz and Nagl, Martin and Bresinsky, Merlin and Monnich, Denise and Seibel, Ulla and Kuder, Kamil J. and Kotanska, Magdalena and Stark, Holger and Elz, Sigurd and Kiec-Kononowicz, Katarzyna (2021) Structural modifications in the distal, regulatory region of histamine H-3 receptor antagonists leading to the identification of a potent anti-obesity agent. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 213: 113041. ISSN 0223-5234, 1768-3254

Sellmer, Andreas and Pilsl, Bernadette and Beyer, Mandy and Pongratz, Herwig and Wirth, Lukas and Elz, Sigurd and Dove, Stefan and Henninger, Sven Julian and Spiekermann, Karsten and Polzer, Harald and Klaeger, Susan and Kuster, Bernhard and Boehmer, Frank D. and Fiebig, Heinz-Herbert and Kraemer, Oliver H. and Mahboobi, Siavosh (2020) A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 193: 112232. ISSN 0223-5234, 1768-3254

Pockes, Steffen and Wifling, David and Buschauer, Armin and Elz, Sigurd (2019) Structure-Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands. CHEMISTRYOPEN, 8 (3). pp. 285-297. ISSN 2191-1363

Leonhardt, Michel and Sellmer, Andreas and Kraemer, Oliver H. and Dove, Stefan and Elz, Sigurd and Kraus, Birgit and Beyer, Mandy and Mahboobi, Siavosh (2018) Design and biological evaluation of tetrahydro-beta-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 152. pp. 329-357. ISSN 0223-5234, 1768-3254

Pockes, Steffen and Wifling, David and Keller, Max and Buschauer, Armin and Elz, Sigurd (2018) Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H-2 Receptor Agonists. ACS OMEGA, 3 (3). pp. 2865-2882. ISSN 2470-1343

Sellmer, Andreas and Stangl, Hubert and Beyer, Mandy and Gruenstein, Elisabeth and Leonhardt, Michel and Pongratz, Herwig and Eichhorn, Emerich and Elz, Sigurd and Striegl, Birgit and Jenei-Lanzl, Zsuzsa and Dove, Stefan and Straub, Rainer H. and Kraemer, Oliver H. and Mahboobi, Siavosh (2018) Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 61 (8). pp. 3454-3477. ISSN 0022-2623, 1520-4804

Hammer, Sebastian G. and Gobleder, Susanne and Naporra, Franziska and Wittmann, Hans-Joachim and Elz, Sigurd and Heinrich, Markus R. and Strasser, Andrea (2016) 2,4-Diaminopyrimidines as dual ligands at the histamine H-1 and H-4 receptor-H-1/H-4-receptor selectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26 (2). pp. 292-300. ISSN 0960-894X, 1464-3405

Naporra, Franziska and Gobleder, Susanne and Wittmann, Hans Joachim and Spindler, Julia and Bodensteiner, Michael and Bernhardt, Guenther and Huebner, Harald and Gmeiner, Peter and Elz, Sigurd and Strasser, Andrea (2016) Dibenzo[bf][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs. PHARMACOLOGICAL RESEARCH, 113. pp. 610-625. ISSN 1043-6618

Baumeister, Paul and Erdmann, Daniela and Biselli, Sabrina and Kagermeier, Nicole and Elz, Sigurd and Bernhardt, Guenther and Buschauer, Armin (2015) [H-3]UR-DE257: Development of a Tritium-Labeled Squaramide-Type Selective Histamine H-2 Receptor Antagonist. CHEMMEDCHEM, 10 (1). pp. 83-93. ISSN 1860-7179, 1860-7187

Wagner, Eva and Wittmann, Hans-Joachim and Elz, Sigurd and Strasser, Andrea (2014) Pharmacological profile of astemizole-derived compounds at the histamine H-1 and H-4 receptor-H-1/H-4 receptor selectivity. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 387 (3). pp. 235-250. ISSN 0028-1298, 1432-1912

Geyer, Roland and Igel, Patrick and Kaske, Melanie and Elz, Sigurd and Buschauer, Armin (2014) Synthesis, SAR and selectivity of 2-acyl-and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach. MEDCHEMCOMM, 5 (1). pp. 72-81. ISSN 2040-2503, 2040-2511

Sadek, Bassem and Alisch, Rudi and Buschauer, Armin and Elz, Sigurd (2013) Synthesis and Dual Histamine H-1 and H-2 Receptor Antagonist Activity of Cyanoguanidine Derivatives. MOLECULES, 18 (11). pp. 14186-14202. ISSN 1420-3049

Birnkammer, Tobias and Spickenreither, Anja and Brunskole, Irena and Lopuch, Miroslaw and Kagermeier, Nicole and Bernhardt, Guenther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2012) The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-Type Histamine H-2 Receptor Agonists. JOURNAL OF MEDICINAL CHEMISTRY, 55 (3). pp. 1147-1160. ISSN 0022-2623, 1520-4804

Pertz, Heinz H. and Lehmann, Jochen and Roth-Ehrang, Rene and Elz, Sigurd (2011) Effects of Ginger Constituents on the Gastrointestinal Tract: Role of Cholinergic M-3 and Serotonergic 5-HT3 and 5-HT4 Receptors. PLANTA MEDICA, 77 (10). pp. 973-978. ISSN 0032-0943, 1439-0221

Wagner, Eva and Wittmann, Hans-Joachim and Elz, Sigurd and Strasser, Andrea (2011) Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21 (21). pp. 6274-6280. ISSN 0960-894X

Wittmann, Hans-Joachim and Elz, Sigurd and Seifert, Roland and Strasser, Andrea (2011) N (alpha)-Methylated phenylhistamines exhibit affinity to the hH(4)R-a pharmacological and molecular modelling study. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 384 (3). pp. 287-299. ISSN 0028-1298, 1432-1912

Silva, Maria Elena and Heim, Ralf and Strasser, Andrea and Elz, Sigurd and Dove, Stefan (2011) Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 25 (1). pp. 51-66. ISSN 0920-654X

Ghorai, Prasanta and Kraus, Anja and Birnkammer, Tobias and Geyer, Roland and Bernhardt, Guenther and Dove, Stefan and Seifert, Roland and Elz, Sigurd and Buschauer, Armin (2010) Chiral N-G-acylated hetarylpropylguanidine-type histamine H-2 receptor agonists do not show significant stereoselectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20 (10). pp. 3173-3176. ISSN 0960-894X

Strasser, Andrea and Wittmann, Hans-Joachim and Kunze, Marc and Elz, Sigurd and Seifert, Roland (2009) Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H-1-Receptor Compared with the Guinea Pig H-1-Receptor. MOLECULAR PHARMACOLOGY, 75 (3). pp. 454-465. ISSN 0026-895X

Kraus, Anja and Ghorai, Prasanta and Birnkammer, Tobias and Schnell, David and Elz, Sigurd and Seifert, Roland and Dove, Stefan and Bernhardt, Guenther and Buschauer, Armin (2009) N-G-Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H-2 Receptor Agonists. CHEMMEDCHEM, 4 (2). pp. 232-240. ISSN 1860-7179

Igel, Patrick and Schneider, Erich and Schnell, David and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2009) N-G-Acylated Imidazolylpropylguanidines as Potent Histamine H-4 Receptor Agonists: Selectivity by Variation of the N-G-Substituent. JOURNAL OF MEDICINAL CHEMISTRY, 52 (8). pp. 2623-2627. ISSN 0022-2623, 1520-4804

Ghorai, Prasanta and Kraus, Anja and Keller, Max and Goette, Carsten and Igel, Patrick and Schneider, Erich and Schnell, David and Bernhardt, Guenther and Dove, Stefan and Zabel, Manfred and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2008) Acylguanidines as Bioisosteres of Guanidines: N-G-Acylated Imidazolylpropylguanidines, a New Class of Histamine H-2 Receptor Agonists. JOURNAL OF MEDICINAL CHEMISTRY, 51 (22). pp. 7193-7204. ISSN 0022-2623, 1520-4804

Mahboobi, Siavosh and Sellmer, Andreas and Eswayah, Asma and Elz, Sigurd and Uecker, Andrea and Boehmer, Frank-D. (2008) Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl) amides - A SAR study on the bioisosterism of pyrimidine and imidazole. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 43 (7). pp. 1444-1453. ISSN 0223-5234

Mahboobi, Siavosh and Uecker, Andrea and Cenac, Christophe and Sellmer, Andreas and Eichhorn, Emerich and Elz, Sigurd and Boehmer, Frank-D. and Dove, Stefan (2007) Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. BIOORGANIC & MEDICINAL CHEMISTRY, 15 (5). pp. 2187-2197. ISSN 0968-0896

Mahboobi, Siavosh and Eichhorn, Emerich and Popp, Alfred and Sellmer, Andreas and Elz, Sigurd and Moellmann, Ute (2006) 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 41 (2). pp. 176-191. ISSN 0223-5234

Xie, Sheng-Xue and Kraus, Anja and Ghorai, Prasanta and Ye, Qi-Zhuang and Elz, Sigurd and Buschauer, Armin and Seifert, Roland (2006) N-1-(3-cyclohexylbutanoyl)-N-2-[3-(1H-imidazol-4yl) propyl] guanidine (UR-AK57), a potent partial agonist for the human histamine H-1- and H-2-receptors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 317 (3). pp. 1262-1268. ISSN 0022-3565, 1521-0103

Mahboobi, Siavosh and Uecker, Andrea and Sellmer, Andreas and Cenac, Christophe and Hoecher, Heymo and Pongratz, Herwig and Eichhorn, Emerich and Hufsky, Harald and Truempler, Antje and Sicker, Marit and Heidel, Florian and Fischer, Thomas and Stocking, Carol and Elz, Sigurd and Boehmer, Frank-D. and Dove, Stefan (2006) Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. JOURNAL OF MEDICINAL CHEMISTRY, 49 (11). pp. 3101-3115. ISSN 0022-2623, 1520-4804

Patil, Rameshwar and Elz, Sigurd and Reiser, Oliver (2006) Side-chain modified analogues of histaprodifen: Asymmetric synthesis and histamine H-1-receptor activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16 (3). pp. 672-676. ISSN 0960-894X, 1464-3405

Pertz, Heinz H. and Elz, Sigurd and Schunack, Walter (2004) Structure-activity relationships of histamine H-1-receptor agonists. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 4 (9). pp. 935-940. ISSN 1389-5575

Dove, Stefan and Elz, Sigurd and Seifert, Roland and Buschauer, Armin (2004) Structure-activity relationships of histamine H-2 receptor ligands. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 4 (9). pp. 941-954. ISSN 1389-5575, 1875-5607

Sadek, B. and Elz, Sigurd and Pertz, H. H. and Stark, H. and Schunack, W. (2004) Unexpected partial H-1-receptor agonism of imidazole-type histamine H-3-receptor antagonists lacking a basic side chain. INFLAMMATION RESEARCH, 53. S109-S115. ISSN 1023-3830, 1420-908X

Menghin, S. and Pertz, Heinz H. and Kramer, K. and Seifert, Roland and Schunack, W. and Elz, Sigurd (2003) N-alpha-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: Synthesis and in vitro evaluation of highly potent histamine H-1-receptor agonists. JOURNAL OF MEDICINAL CHEMISTRY, 46 (25). pp. 5458-5470. ISSN 0022-2623, 1520-4804

Govoni, M. and Bakker, R. A. and van de Wetering, I.. and Smit, M. J. and Menge, W. M. B. P. and Timmerman, H and Elz, Sigurd and Schunack, W. and Leurs, R. (2003) Synthesis and pharmacological identification of neutral histamine H-1-receptor antagonists. JOURNAL OF MEDICINAL CHEMISTRY, 46 (26). pp. 5812-5824. ISSN 0022-2623, 1520-4804

El-Subbagh, Hussein and Wittig, Thomas and Decker, Michael and Elz, Sigurd and Nieger, Martin and Lehmann, Jochen (2002) Dopamine/serotonin receptor ligands. Part IV [1]: Synthesis and pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT2A and dopamine receptor ligands. ARCHIV DER PHARMAZIE, 335 (9). pp. 443-448. ISSN 0365-6233, 1521-4184

Sasse, Astrid and Ligneau, Xavier and Rouleau, Agnes and Elz, Sigurd and Ganellin, C. Robin and Arrang, Jean-Michel and Schwartz, Jean-Charles and Schunack, Walter and Stark, Holger (2002) Influence of bulky substituents on histamine H-3 receptor agonist/antagonist properties. JOURNAL OF MEDICINAL CHEMISTRY, 45 (18): UNSP JM020. pp. 4000-4010. ISSN 0022-2623

Lazewska, Dorota and Kiec-Kononowicz, Katarzyna and Pertz, H. H. and Elz, Sigurd and Stark, Holger and Schunack, W. (2002) Piperidine-containing histamine H-3 receptor antagonists of the carbamate series: the influence of the additional ether functionality. PHARMAZIE, 57 (12). pp. 791-795. ISSN 0031-7144

Grassmann, Sven and Sadek, Bassem and Ligneau, Xavier and Elz, Sigurd and Ganellin, C. Robin and Arrang, Jean-Michel and Schwartz, Jean-Charles and Stark, Holger and Schunack, Walter (2002) Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H-3-receptor antagonists. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 15 (4): PII S0928-. pp. 367-378. ISSN 0928-0987, 1879-0720

Lazewska, Dorota and Kiec-Kononowicz, Katarzyna and Pertz, H. H. and Stark, Holger and Schunack, W. and Elz, Sigurd (2001) Piperidine-containing histamine H-3-receptor antagonists of the carbamate series: variation of the spacer length. PHARMAZIE, 56 (12). pp. 927-932. ISSN 0031-7144

Rostom, Sherif A. F. and Farghaly, Ahmed M. and Soliman, Farid S. G. and El-Semary, Mona M. and Elz, Sigurd and Lehmann, Jochen (2001) Synthesis and 5-HT2A antagonist activity of derivatives of the novel heterocycles indolo[3,2-d]pyrrolo[3,2-g]azecine and benzo[d]pyrrolo[3,2-g]azecine compared to the benz[d]indolo[2,3-g]azecine derivative LE 300. ARCHIV DER PHARMAZIE, 334 (7). pp. 241-247. ISSN 0365-6233

Conference or Workshop Item

Elz, Sigurd and Paraschiv, G.-I. and Patil, R. and Kunze, M. and Striegl, B. and Sunel, V. and Cecal, A. and Buschauer, Armin and Reiser, Oliver (2005) New side-chain modified histamine derivatives as ligands for histamine H-1-receptors. In: 46th Spring Meeting of the Deutsche Gesellschaft fuer Experimentelle und Klinische Pharmakologie und Toxikologie, March 15-17, 2005, Mainz, Germany.