Items where Author is "Lebek, Simon"

Article

Wester, Michael and Lebek, Simon (2024) Breathless Nights and Cardiac Frights-How Snoring Is Breaking Hearts. BIOMEDICINES, 12 (12): 2695. ISSN 2227-9059

Lebek, Simon and Caravia, Xurde M. and Straub, Leon G. and Alzhanov, Damir and Tan, Wei and Li, Hui and McAnally, John R. and Chen, Kenian and Xu, Lin and Scherer, Philipp E. and Liu, Ning and Bassel-Duby, Rhonda and Olson, Eric N. (2024) CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model. JOURNAL OF CLINICAL INVESTIGATION, 134 (1): e175164. ISSN 0021-9738, 1558-8238

Hegner, Philipp and Ofner, Florian and Schaner, Benedikt and Gugg, Mathias and Trum, Maximilian and Lauerer, Anna-Maria and Maier, Lars Siegfried and Arzt, Michael and Lebek, Simon and Wagner, Stefan (2024) CaMKIIδ-dependent dysregulation of atrial Na<SUP>+</SUP> homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model. FRONTIERS IN PHARMACOLOGY, 15: 1411822. ISSN , 1663-9812

Trum, Maximilian and Riechel, Johannes and Schollmeier, Elisa and Lebek, Simon and Hegner, Philipp and Reuthner, Kathrin and Heers, Silvia and Keller, Karoline and Wester, Michael and Klatt, Susanne and Hamdani, Nazha and Provaznik, Zdenek and Schmid, Christof and Maier, Lars and Arzt, Michael and Wagner, Stefan (2024) Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF. CARDIOVASCULAR RESEARCH, 120 (9). pp. 999-1010. ISSN 0008-6363, 1755-3245

Hegner, Philipp and Wester, Michael and Tafelmeier, Maria and Provaznik, Zdenek and Klatt, Susanne and Schmid, Christof and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan and Lebek, Simon (2024) Systemic inflammation predicts diastolic dysfunction in patients with sleep disordered breathing. EUROPEAN RESPIRATORY JOURNAL, 63 (6): 2400579. ISSN 0903-1936, 1399-3003

Lebek, Simon and Chemello, Francesco and Caravia, Xurde M. and Tan, Wei and Li, Hui and Chen, Kenian and Xu, Lin and Liu, Ning and Bassel-Duby, Rhonda and Olson, Eric N. (2023) Ablation of CaMKIId oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease. SCIENCE, 379 (6628). pp. 179-185. ISSN 0036-8075, 1095-9203

Hegner, Philipp and Lebek, Simon and Schaner, Benedikt and Ofner, Florian and Gugg, Mathias and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2023) CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea. ANTIOXIDANTS, 12 (2): 315. ISSN , 2076-3921

Lebek, Simon and Caravia, Xurde M. and Chemello, Francesco and Tan, Wei and McAnally, John R. and Chen, Kenian and Xu, Lin and Liu, Ning and Bassel-Duby, Rhonda and Olson, Eric N. (2023) Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice. CIRCULATION, 148 (19). pp. 1490-1504. ISSN 0009-7322, 1524-4539

Mustroph, Julian and Baier, Maria J. J. and Unsin, Denise and Provaznik, Zdenek and Kozakov, Kostiantyn and Lebek, Simon and Tarnowski, Daniel and Schildt, Soenke and Voigt, Niels and Wagner, Stefan and Maier, Lars S. S. and Neef, Stefan (2023) Ethanol-Induced Atrial Fibrillation Results From Late INa and Can Be Prevented by Ranolazine. CIRCULATION, 148 (8). pp. 698-700. ISSN 0009-7322, 1524-4539

Wester, Michael and Arzt, Michael and Sinha, Frederick and Maier, Lars Siegfried and Lebek, Simon (2023) Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing. BIOMEDICINES, 11 (11): 3038. ISSN 2227-9059

Arzt, Michael and Drzymalski, Marzena A. and Ripfel, Sarah and Meindl, Sebastian and Biedermann, Alexander and Durczok, Melanie and Keller, Karoline and Mustroph, Julian and Katz, Sylvia and Tafelmeier, Maria and Lebek, Simon and Floerchinger, Bernhard and Camboni, Daniele and Wittmann, Sigrid and Backs, Johannes and Schmid, Christof and Maier, Lars S. and Wagner, Stefan (2022) Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing. ANTIOXIDANTS, 11 (2): 331. ISSN , 2076-3921

Wester, Michael and Pec, Jan and Lebek, Simon and Fisser, Christoph and Debl, Kurt and Hamer, Okka and Poschenrieder, Florian and Buchner, Stefan and Maier, Lars S. and Arzt, Michael and Wagner, Stefan (2022) Sleep-Disordered Breathing Is Associated With Reduced Left Atrial Strain Measured by Cardiac Magnetic Resonance Imaging in Patients After Acute Myocardial Infarction. FRONTIERS IN MEDICINE, 9: 759361. ISSN , 2296-858X

Lebek, Simon and Hegner, Philipp and Hultsch, Rosa and Rohde, Jonas and Rupprecht, Leopold and Schmid, Christof and Sossalla, Samuel and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2022) Voltage-Gated Sodium Channel Na(V)1.8 Dysregulates Na and Ca, Leading to Arrhythmias in Patients with Sleep-Disordered Breathing. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 206 (11). pp. 1428-1431. ISSN 1073-449X, 1535-4970

Lebek, Simon and Wester, Michael and Pec, Jan and Poschenrieder, Florian and Tafelmeier, Maria and Fisser, Christoph and Provaznik, Zdenek and Schopka, Simon and Debl, Kurt and Schmid, Christof and Buchner, Stefan and Maier, Lars S. and Arzt, Michael and Wagner, Stefan (2021) Abnormal P-wave terminal force in lead V-1 is a marker for atrial electrical dysfunction but not structural remodelling. ESC HEART FAILURE, 8 (5). pp. 4055-4066. ISSN 2055-5822,

Hegner, Philipp and Lebek, Simon and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2021) The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea. FRONTIERS IN PHYSIOLOGY, 12: 741896. ISSN 1664-042X

Islam, M. M. Towhidul and Tarnowski, Daniel and Zhang, Min and Trum, Maximilian and Lebek, Simon and Mustroph, Julian and Daniel, Henriette and Moellencamp, Johanna and Pabel, Steffen and Sossalla, Samuel and El-Armouche, Ali and Nikolaev, Viacheslav O. and Shah, Ajay M. and Eaton, Philip and Maier, Lars S. and Sag, Can Martin and Wagner, Stefan (2021) Enhanced Heart Failure in Redox-Dead Cys17Ser PKARI alpha Knock-In Mice. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10 (19): e021985. ISSN , 2047-9980

Lebek, Simon and Hegner, Philipp and Tafelmeier, Maria and Rupprecht, Leopold and Schmid, Christof and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2021) Female Patients With Sleep-Disordered Breathing Display More Frequently Heart Failure With Preserved Ejection Fraction. FRONTIERS IN MEDICINE, 8: 675987. ISSN , 2296-858X

Hegner, Philipp and Lebek, Simon and Tafelmeier, Maria and Camboni, Daniele and Schopka, Simon and Schmid, Christof and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2021) Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression. HEART RHYTHM, 18 (12). pp. 2187-2194. ISSN 1547-5271, 1556-3871

Lebek, Simon and Tafelmeier, Maria and Messmann, Rebecca and Provaznik, Zdenek and Schmid, Christof and Maier, Lars S. and Birner, Christoph and Arzt, Michael and Wagner, Stefan (2020) Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiacmRNAexpression of angiotensin-converting enzyme2in patients with cardiovascular disease. EUROPEAN JOURNAL OF HEART FAILURE, 22 (12). pp. 2248-2257. ISSN 1388-9842, 1879-0844

Pabel, Steffen and Mustroph, Julian and Stehle, Thea and Lebek, Simon and Dybkova, Nataliya and Keyser, Andreas and Rupprecht, Leopold and Wagner, Stefan and Neef, Stefan and Maier, Lars S. and Sossalla, Samuel (2020) Dantrolene reduces CaMKII delta C-mediated atrial arrhythmias. EUROPACE, 22 (7). pp. 1111-1118. ISSN 1099-5129, 1532-2092

Trum, Maximilian and Riechel, Johannes and Lebek, Simon and Pabel, Steffen and Sossalla, Samuel T. and Hirt, Stephan and Arzt, Michael and Maier, Lars S. and Wagner, Stefan (2020) Empagliflozin inhibits Na+/H(+)exchanger activity in human atrial cardiomyocytes. ESC HEART FAILURE, 7 (6). pp. 4429-4437. ISSN 2055-5822

Lebek, Simon and Pichler, Konstantin and Reuthner, Kathrin and Trum, Maximillian and Tafelmeier, Maria and Mustroph, Julian and Camboni, Daniele and Rupprecht, Leopold and Schmid, Christof and Maier, Lars S. and Arzt, Michael and Wagner, Stefan (2020) Enhanced CaMKII-Dependent Late I-Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing. CIRCULATION RESEARCH, 126 (5). pp. 603-615. ISSN 0009-7330, 1524-4571

Lebek, Simon and Hegner, Philipp and Schach, Christian and Reuthner, Kathrin and Tafelmeier, Maria and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2020) A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction. PLOS ONE, 15 (12): e0243844. ISSN 1932-6203

Tafelmeier, Maria and Knapp, Marvin and Lebek, Simon and Floerchinger, Bernhard and Camboni, Daniele and Creutzenberg, Marcus and Wittmann, Sigrid and Zeman, Florian and Schmid, Christof and Maier, Lars Siegfried and Wagner, Stefan and Arzt, Michael (2019) Predictors of delirium after cardiac surgery in patients with sleep disordered breathing. EUROPEAN RESPIRATORY JOURNAL, 54 (2): 1900354. ISSN 0903-1936, 1399-3003

Mustroph, Julian and Wagemann, Olivia and Luecht, Charlotte M. and Trum, Maximilian and Hammer, Karin P. and Sag, Can Martin and Lebek, Simon and Tarnowski, Daniel and Reinders, Joerg and Perbellini, Filippo and Terracciano, Cesare and Schmid, Christof and Schopka, Simon and Hilker, Michael and Zausig, York and Pabel, Steffen and Sossalla, Samuel T. and Schweda, Frank and Maier, Lars S. and Wagner, Stefan (2018) Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes. ESC HEART FAILURE, 5 (4). pp. 642-648. ISSN 2055-5822

Neef, Stefan and Steffens, Alexander and Pellicena, Patricia and Mustroph, Julian and Lebek, Simon and Ort, Katharina R. and Schulman, Howard and Maier, Lars S. (2018) Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 115. pp. 73-81. ISSN 0022-2828, 1095-8584

Mustroph, Julian and Wagemann, Olivia and Lebek, Simon and Tarnowski, Daniel and Ackermann, Jasmin and Drzymalski, Marzena and Pabel, Steffen and Schmid, Christof and Wagner, Stefan and Sossalla, Samuel and Maier, Lars S. and Neef, Stefan (2018) SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 116. pp. 81-90. ISSN 0022-2828, 1095-8584

Conference or Workshop Item

Baier, Maria J. and Mustroph, Julian and Unsin, Denise and Lebek, Simon and Tarnowski, Daniel and Provaznik, Zdenek and Voigt, Niels and Wagner, Stefan and Maier, Lars S. and Neef, Stefan (2023) Ethanol-induced atrial fibrillation results from late INa and can be prevented by ranolazine. In: Annual Meeting of the European Society of Cardiology (ESC), August 25-28, 2023, Amsterdam, Netherlands.

Zilch, Johannes and Tafelmeier, Maria and Lebek, Simon and Hirt, Stephan and Floerchinger, Bernhard and Camboni, Daniele and Creutzenberg, Marcus and Zeman, Florian and Schmid, Christof and Maier, Lars S. and Wagner, Stefan and Arzt, Michael (2020) Impact of sleep-disordered breathing on sternal wound complications after elective coronary artery bypass grafting surgery. In: ERS International Congress 2020, 07.09. bis 09.09.2020, Virtuell.

Other

Mustroph, Julian and Lebek, Simon and Maier, Lars S. and Neef, Stefan (2019) Mechanisms of cardiac ethanol toxicity and novel treatment options. PERGAMON-ELSEVIER SCIENCE LTD, OXFORD.

Tafelmeier, Maria and Knapp, Marvin and Lebek, Simon and Floerchinger, Bernhard and Camboni, Daniele and Creutzenberg, Marcus and Wittmann, Sigrid and Zeman, Florian and Schmid, Christof and Maier, Lars S. and Wagner, Stefan and Arzt, Michael (2019) Predictors of postoperative delirium after elective coronary artery bypass grafting surgery in patients with and without sleep-disordered breathing - a prospective observational study. EUROPEAN RESPIRATORY SOC JOURNALS LTD, SHEFFIELD.