Items where Author is "Wifling, David"

Article

Weinhart, Corinna G. and Wifling, David and Schmidt, Maximilian F. and Neu, Eduard and Hoering, Carina and Clark, Timothy and Gmeiner, Peter and Keller, Max (2021) Dibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on M2R selectivity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 213: 113159. ISSN 0223-5234, 1768-3254

Konieczny, Adam and Conrad, Marcus and Ertl, Fabian J. and Gleixner, Jakob and Gattor, Albert O. and Graetz, Lukas and Schmidt, Maximilian F. and Neu, Eduard and Horn, Anselm H. C. and Wifling, David and Gmeiner, Peter and Clark, Timothy and Sticht, Heinrich and Keller, Max (2021) N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y-4 Receptor Ligands Results in Picomolar Binding Constants. JOURNAL OF MEDICINAL CHEMISTRY, 64 (22). pp. 16746-16769. ISSN 0022-2623, 1520-4804

Antoni, Frauke and Wifling, David and Bernhardt, Guenther (2021) Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 210: 112958. ISSN 0223-5234, 1768-3254

Buschmann, Jonas and Seiler, Theresa and Bernhardt, Guenther and Keller, Max and Wifling, David (2020) Argininamide-type neuropeptide Y Y-1 receptor antagonists: the nature of N-omega-carbamoyl substituents determines Y1R binding mode and affinity. RSC MEDICINAL CHEMISTRY, 11 (2). pp. 274-282. ISSN 2632-8682

Konieczny, Adam and Braun, Diana and Wifling, David and Bernhardt, Guenther and Keller, Max (2020) Oligopeptides as Neuropeptide Y Y-4 Receptor Ligands: Identification of a High-Affinity Tetrapeptide Agonist and a Hexapeptide Antagonist. JOURNAL OF MEDICINAL CHEMISTRY, 63 (15). pp. 8198-8215. ISSN 0022-2623, 1520-4804

She, Xueke and Pegoli, Andrea and Gruber, Corinna G. and Wifling, David and Carpenter, Jessica and Huebner, Harald and Chen, Mengya and Wan, Jianfei and Bernhardt, Guenther and Gmeiner, Peter and Holliday, Nicholas D. and Keller, Max (2020) Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M-2 Receptor. JOURNAL OF MEDICINAL CHEMISTRY, 63 (8). pp. 4133-4154. ISSN 0022-2623, 1520-4804

Bartole, Edith and Graetz, Lukas and Littmann, Timo and Wifling, David and Seibel, Ulla and Buschauer, Armin and Bernhardt, Guenther (2020) UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H-3 and H-4 Receptors. JOURNAL OF MEDICINAL CHEMISTRY, 63 (10). pp. 5297-5311. ISSN 0022-2623, 1520-4804

Wifling, David and Pfleger, Christopher and Kaindl, Jonas and Ibrahim, Passainte and Kling, Ralf C. and Buschauert, Armin and Gohlke, Holger and Clark, Timothy (2019) Basal Histamine H-4 Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif. CHEMISTRY-A EUROPEAN JOURNAL, 25 (64). pp. 14613-14624. ISSN 0947-6539, 1521-3765

Pegoli, Andrea and Wifling, David and Gruber, Corinna G. and She, Xueke and Huebner, Harald and Bernhardt, Guenther and Gmeiner, Peter and Keller, Max (2019) Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity. JOURNAL OF MEDICINAL CHEMISTRY, 62 (11). pp. 5358-5369. ISSN 0022-2623, 1520-4804

Pockes, Steffen and Wifling, David and Buschauer, Armin and Elz, Sigurd (2019) Structure-Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands. CHEMISTRYOPEN, 8 (3). pp. 285-297. ISSN 2191-1363

Ibrahim, Passainte and Wifling, David and Clark, Timothy (2019) Universal Activation Index for Class A GPCRs. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 59 (9). pp. 3938-3945. ISSN 1549-9596, 1549-960X

Pockes, Steffen and Wifling, David and Keller, Max and Buschauer, Armin and Elz, Sigurd (2018) Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H-2 Receptor Agonists. ACS OMEGA, 3 (3). pp. 2865-2882. ISSN 2470-1343

Yang, Zhenlin and Han, Shuo and Keller, Max and Kaiser, Anette and Bender, Brian J. and Bosse, Mathias and Burkert, Kerstin and Koegler, Lisa M. and Wifling, David and Bernhardt, Guenther and Plank, Nicole and Littmann, Timo and Schmidt, Peter and Yi, Cuiying and Li, Beibei and Ye, Sheng and Zhang, Rongguang and Xu, Bo and Larhammar, Dan and Stevens, Raymond C. and Huster, Daniel and Meiler, Jens and Zhao, Qiang and Beck-Sickinger, Annette G. and Buschauer, Armin and Wu, Beili (2018) Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor. NATURE, 556 (7702). 520-+. ISSN 0028-0836, 1476-4687

Pegoli, Andrea and She, Xueke and Wifling, David and Huebner, Harald and Bernhardt, Guenther and Gmeiner, Peter and Keller, Max (2017) Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M-2 Muscarinic Acetylcholine Receptor. JOURNAL OF MEDICINAL CHEMISTRY, 60 (8). pp. 3314-3334. ISSN 0022-2623, 1520-4804

Keller, Max and Kuhn, Kilian K. and Einsiedel, Juergen and Huebner, Harald and Biselli, Sabrina and Mollereau, Catherine and Wifling, David and Svobodova, Jaroslava and Bernhardt, Guenther and Cabrele, Chiara and Vanderheyden, Patrick M. L. and Gmeiner, Peter and Buschauer, Armin (2016) Mimicking of Arginine by Functionalized N-omega-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples. JOURNAL OF MEDICINAL CHEMISTRY, 59 (5). pp. 1925-1945. ISSN 0022-2623, 1520-4804

Wifling, David and Bernhardt, Guenther and Dove, Stefan and Buschauer, Armin (2015) The Extracellular Loop 2 (ECL2) of the Human Histamine H-4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity. PLOS ONE, 10 (1): e0117185. ISSN 1932-6203

Nordemann, Uwe and Wifling, David and Schnell, David and Bernhardt, Guenther and Stark, Holger and Seifert, Roland and Buschauer, Armin (2013) Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H-4 Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts. PLOS ONE, 8 (9): e73961. ISSN 1932-6203