Valenza, Giuseppe and Schulze, Monika and Friedrich, Petra and Schneider-Brachert, Wulf and Holzmann, Thomas and Nickel, Silke and Lehner-Reindl, Verena and Hoeller, Christiane (2017) Screening of ESBL-producing Enterobacteriacae concomitant with low degree of transmission in intensive care and bone marrow transplant units. INFECTIOUS DISEASES, 49 (5). pp. 405-409. ISSN 2374-4235, 2374-4243
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Background: Extended-spectrum -lactamase-producing Enterobacteriaceae (ESBL-E) are spreading worldwide in both hospital and community settings. In this study, the molecular epidemiology and the transmission modalities of ESBL-E in intensive care- and bone marrow transplant were investigated. Methods: All patients included in this study were screened for presence of ESBL-E on admission and weekly. Relevant -lactamase genes were identified by PCR and sequencing. Results: A total of 669 patients were included in this study. On admission, ESBL-producing Escherichia coli were detected in 49 (7.3%) patients and ESBL-producing Klebsiella pneumoniae in one patient. The most common ESBL types among E. coli isolates were CTX-M-15 (38.8%) and CTX-M-1 (38.8%). Furthermore, 12 of 49 (24.5%) ESBL-producing E. coli could be assigned to the epidemic clone ST131. A single patient acquired ESBL-producing E. coli during the hospital stay but cross-transmission could not be demonstrated. Among 1095 environmental samples none revealed ESBL. Conclusions: Our results suggest that early detection of ESBL-producing Enterobacteriaceae and consequent implementation of basic hygiene measures and contact isolation may reduce the transmission rate during the hospital stay.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPECTRUM-BETA-LACTAMASE; ESCHERICHIA-COLI; CLONE; DISSEMINATION; Escherichia coli; ESBL; ST131; hospital; carriage; transmission |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 12:58 |
| Last Modified: | 20 Feb 2019 13:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/100 |
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