Spaeth, Andreas and Leibl, Christoph and Cieplik, Fabian and Lehner, Karin and Regensburger, Johannes and Hiller, Karl-Anton and Baeumler, Wolfgang and Schmalz, Gottfried and Maisch, Tim (2014) Improving Photodynamic Inactivation of Bacteria in Dentistry: Highly Effective and Fast Killing of Oral Key Pathogens with Novel Tooth-Colored Type-II Photosensitizers. JOURNAL OF MEDICINAL CHEMISTRY, 57 (12). pp. 5157-5168. ISSN 0022-2623, 1520-4804
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Increasing antibiotic resistances in microorganisms create serious problems in public health. This demands alternative approaches for killing pathogens to supplement standard treatment methods. Photodynamic inactivation of bacteria (PIB) uses light activated photosensitizers (PS) to generate reactive oxygen species immediately upon illumination, inducing lethal phototoxicity. Positively charged phenalen-1-one derivatives are a new generation of PS for light-mediated killing of pathogens with outstanding singlet oxygen quantum yield Phi(Delta) of >97%. Upon irradiation with a standard photopolymerizer light (bluephase C8, 1260 +/- 50 mW/cm(2)) the PS showed high activity against the oral key pathogens Enterococcus faecalis, Actinomyces naeslundii, Streptococcus mutans, and Aggregatibacter actinomycetemcomitans. At a concentration of 10 mu M, a maximum efficacy of more than 6 log(10) steps (>= 99.9999%) of bacteria killing is reached in less than 1 min (light dose 50 J/cm(2)) after one single treatment. The pyridinium substituent as positively charged moiety is especially advantageous for antimicrobial action.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SINGLET OXYGEN; STAPHYLOCOCCUS-AUREUS; PHENALENONE PHYTOALEXINS; STREPTOCOCCUS-MUTANS; DENTAL BIOFILM; THERAPY; PERIODONTITIS; RESISTANCE; LIGHT; ACTINOMYCETEMCOMITANS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie Chemistry and Pharmacy > Institut für Organische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Oct 2019 13:07 |
| Last Modified: | 17 Oct 2019 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10008 |
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