Slegtenhorst, Bendix R. and Dor, Frank J. M. F. and Elkhal, Abdala and Rodriguez, Hector and Yang, Xiaoyong and Edtinger, Karoline and Quante, Markus and Chong, Anita S. and Tullius, Stefan G. (2014) Mechanisms and Consequences of Injury and Repair in Older Organ Transplants. TRANSPLANTATION, 97 (11). pp. 1091-1099. ISSN 0041-1337, 1534-6080
Full text not available from this repository. (Request a copy)Abstract
Donor organ scarcity remains a significant clinical challenge in transplantation. Older organs, increasingly utilized to meet the growing demand for donor organs, have been linked to inferior transplant outcomes. Susceptibility to organ injury, reduced repair capacity, and increased immunogenicity are interrelated and impacted by physiological and pathological aging processes. Insights into the underlying mechanisms are needed to develop age-specific interventional strategies with regards to organ preservation, immunosuppression, and allocation. In this overview, we summarize current knowledge of injury and repair mechanisms and the effects of aging relevant to transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISCHEMIA-REPERFUSION INJURY; ACUTE KIDNEY INJURY; ENDOPLASMIC-RETICULUM STRESS; CARDIAC ALLOGRAFT VASCULOPATHY; MESENCHYMAL STEM-CELLS; DONORS 55 YEARS; NF-KAPPA-B; MACHINE PERFUSION; COLD-STORAGE; ISCHEMIA/REPERFUSION INJURY; Aging; Transplantation; Injury; Repair |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Jul 2020 10:35 |
| Last Modified: | 30 Jul 2020 10:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10022 |
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