Niller, Hans Helmut and Tarnai, Zsofia and Decsi, Gabor and Zsedenyi, Adam and Banati, Ferenc and Minarovits, Janos (2014) Role of epigenetics in EBV regulation and pathogenesis. FUTURE MICROBIOLOGY, 9 (6). pp. 747-756. ISSN 1746-0913, 1746-0921
Full text not available from this repository. (Request a copy)Abstract
Epigenetic modifications of the viral and host cell genomes regularly occur in EBV-associated lymphomas and carcinomas. The cell type-dependent usage of latent EBV promoters is determined by the cellular epigenetic machinery. Viral oncoproteins interact with the very same epigenetic regulators and alter the cellular epigenotype and gene-expression pattern: there are common gene sets hypermethylated in both EBV-positive and EBV-negative neoplasms of different histological types. A group of hypermethylated promoters may represent, however, a unique EBV-associated epigenetic signature in EBV-positive gastric carcinomas. By contrast, EBV-immortalized B-lymphoblastoid cell lines are characterized by genome-wide demethylation and loss and rearrangement of heterochromatic histone marks. Early steps of EBV infection may also contribute to reprogramming of the cellular epigenome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPSTEIN-BARR-VIRUS; LYMPHOBLASTOID CELL-LINES; LATENT CYCLE PROMOTER; BAMHI W PROMOTER; GENE-EXPRESSION; NASOPHARYNGEAL CARCINOMA; B-CELLS; DNA METHYLATION; BURKITTS-LYMPHOMA; GASTRIC-CARCINOMA; CpG island; DNA methylation; epigenetic regulation; histone modification; hit and run oncogenesis; methylome; pioneer transcription factor; Polycomb repressor complex; tumor suppressor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2019 12:44 |
| Last Modified: | 16 Sep 2019 12:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10061 |
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