Schulz, C. (2014) Biological Agents and Pulmonary Disorders. AKTUELLE RHEUMATOLOGIE, 39 (3). pp. 175-181. ISSN 0341-051X, 1438-9940
Full text not available from this repository. (Request a copy)Abstract
Drug-induced pulmonary disorders are not uncommon in patients with systemic rheumatologic autoimmune diseases. Over the last decade there has been an exponential rise in the use of disease-modifying biological agents to treat auto immune diseases. Current treatment options comprise a group of different biological agents including tumor necrosis factor-a-inhibitors, interleukin-6 receptor blockers, interleukin-1 antagonists, T-cell co-stimulation molecule blockers, and a B-cell depleting antibody. These agents are effective in ameliorating signs, symptoms, radiographic damage, and the natural history of the disease. However, their toxicity profile remains to fully elucidated. Reported noninfectious complications have been published for virtually all biological agents. Incidence rates depend on additional risk factors such as preexisting interstitial lung disease and/or concomitant methotrexate-treatment. Pre-treatment evaluation should include chest radiographs and pulmonary function tests to discard subclinical interstitial lung disease, especially in patients at high risk of pulmonary disorders or patients with respiratory symptoms or signs. If severe interstitial lung disease develop treatment cessation is mandatory together with initiation of corticosteroid treatment and additional immunosuppressive treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERSTITIAL LUNG-DISEASE; ACTIVE RHEUMATOID-ARTHRITIS; NECROSIS-FACTOR-ALPHA; EVERY 4 WEEKS; DOUBLE-BLIND; CERTOLIZUMAB PEGOL; RECEPTOR INHIBITION; AUTOIMMUNE-DISEASES; PHASE-III; ANTIBODY; rheumatological autoimmune disease; biologics; lung diseases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Jul 2020 10:13 |
| Last Modified: | 24 Jul 2020 10:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10077 |
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