Gunia, Sven and Jain, Anjun and Albrecht, Knut and Koch, Stefan and Otto, Wolfgang and Denzinger, Stefan and Goetz, Stefanie and Niessl, Nina and Burger, Maximilian and May, Matthias (2014) Diagnostic and prognostic impact of peritumoral stromal remodeling in patients with surgically treated invasive penile squamous cell cancer. HUMAN PATHOLOGY, 45 (6). pp. 1169-1176. ISSN 0046-8177, 1532-8392
Full text not available from this repository. (Request a copy)Abstract
Stromal remodeling (SR), characterized by focal loss of CD34(+) fibrocytes paralleled by a gain of a-smooth muscle actin (alpha-SMA)-positive myofibroblasts, has been reported in several cancer types. However, the role of SR in invasive penile squamous cell cancer (PSC) has not been investigated so far. We compared 90 surgically treated PSCs (study group) and 55 control specimens (33 foreskins and 22 differentiated penile intraepithelial neoplasias) for the presence of stromal CD34(+) fibrocytes and a-SMA positive myofibroblasts scored by independent raters. Multivariate proportional hazards regression analysis was used to assess the impact of staining profiles on cancer-specific mortality of the 90 PSCs (median follow-up, 32 months; interquartile range, 6-64). The incidence of SR differed significantly between study and control group specimens (51.1% versus 9.1%; P < .001). Five years postsurgically, 24% and 46% of the study patients without and with SR had succumbed to their PSC (P = .010). After adjusting for the age at the time of surgery, type of surgery, tumor size, Broders' grade, pT stage, and nodal status, study patients with SR showed 3.76-fold increased cancer-specific mortality (95% confidence interval, 1.3-10.5; P = .012). Our findings suggest that SR might have prognostic as well as some limited differential diagnostic value in terms of delineating invasive PSC from preinvasive lesions. However, our preliminary data clearly need to be validated by larger advanced studies in the future. (C) 2014 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD34(+) FIBROCYTES; IN-SITU; INTRAEPITHELIAL NEOPLASIA; BREAST-LESIONS; EXPRESSION; CARCINOMAS; BENIGN; Penile squamous cell cancer (PSC); Stromal remodeling (SR); CD34(+) fibrocytes; alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts; Differential diagnosis; Prognostic outcome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Nov 2019 10:39 |
| Last Modified: | 06 Nov 2019 10:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10117 |
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