Eriksson, Joel and Haring, Robin and Grarup, Niels and Vandenput, Liesbeth and Wallaschofski, Henri and Lorentzen, Erik and Hansen, Torben and Mellstrom, Dan and Pedersen, Oluf and Nauck, Matthias and Lorentzon, Mattias and Husemoen, Lise Lotte Nystrup and Voelzke, Henry and Karlsson, Magnus and Baumeister, Sebastian E. and Linneberg, Allan and Ohlsson, Claes (2017) Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PLOS ONE, 12 (4): e0176277. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Design Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Setting Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). Participants 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. Main outcome measures BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. Results 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42-0.09, p = 2.8*10(-3)). For a body weight reduction altering the BMI from 30 to 25 kg/m(2), the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). Conclusions Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HORMONE-BINDING GLOBULIN; BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; ELDERLY-MEN; OLDER MEN; FTO GENE; HYPOGONADOTROPIC HYPOGONADISM; METABOLIC SYNDROME; MUSCLE STRENGTH; RISK-FACTORS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 26 Feb 2019 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1012 |
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