Poeppl, Timm B. and Frank, Elmar and Schecklmann, Martin and Kreuzer, Peter M. and Prasser, S. Julia and Rupprecht, Rainer and Hajak, Goeran and Langguth, Berthold and Landgrebe, Michael (2014) Amygdalohippocampal neuroplastic changes following neuroleptic treatment with quetiapine in first-episode schizophrenia. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 17 (6). pp. 833-843. ISSN 1461-1457, 1469-5111
Full text not available from this repository. (Request a copy)Abstract
Schizophrenia is a severe, debilitating, chronic disease that is accompanied by morphologic changes within the brain. However, it is unclear to what extent alterations of grey and white matter in schizophrenia are linked to the disease itself, or whether they are a consequence of neuroleptic treatment. Typical and atypical antipsychotics exert differential effects on brain structure. Moreover, atypical antipsychotics may have distinct profiles with respect to grey matter in schizophrenic patients. Findings on drug-induced grey matter changes are heterogeneous due to variation in stage of illness, duration of treatment and use of multiple antipsychotics. Using voxel-based morphometry applied to high-resolution magnetic resonance images, we show that monotherapy with the atypical agent quetiapine (mean daily dose=445mg +/- 200s.d.) may induce structural brain changes in first-episode schizophrenia patients (N=20) within 21d of treatment. Specifically, we demonstrate longitudinal macroscopic changes (i.e. grey matter increases) in the left amygdalohippocampal region that were predicted by drug plasma levels but not daily doses. These structural alterations were accompanied by a clinical improvement of schizophrenic symptoms. Comparison with healthy controls (n=30) showed that grey matter amount in the respective amygdalar region was significantly reduced in unmedicated first-episode schizophrenia patients. These findings suggest that drug-induced neuroplastic changes in schizophrenia can occur quickly and are dependent on pharmacokinetics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VOXEL-BASED MORPHOMETRY; ATYPICAL ANTIPSYCHOTIC TREATMENT; NEUROTROPHIC FACTOR EXPRESSION; GRAY-MATTER DIFFERENCES; ENTORHINAL CORTEX; GREY-MATTER; CYTOARCHITECTONIC MAPS; STATISTICAL APPROACH; CLINICAL-RESPONSE; ONSET HYPOTHESIS; Amygdala; entorhinal cortex; first-episode schizophrenia; grey matter; longitudinal voxel-based morphometry; quetiapine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Nov 2019 11:04 |
| Last Modified: | 06 Nov 2019 11:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10129 |
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