Dueck, Anne and Meister, Gunter (2014) Assembly and function of small RNA - Argonaute protein complexes. BIOLOGICAL CHEMISTRY, 395 (6). pp. 611-629. ISSN 1431-6730, 1437-4315
Full text not available from this repository. (Request a copy)Abstract
Small RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or Piwi-interacting RNAs (piRNAs) are important regulators of gene expression in various organisms. Small RNAs bind to a member of the Argonaute protein family and are incorporated into larger structures that mediate diverse gene silencing events. The loading of Argonaute proteins with small RNAs is aided by a number of auxiliary factors as well as ATP hydrolysis. This review will focus on the mechanisms of Argonaute loading in different organisms. Furthermore, we highlight the versatile functions of small RNA-Argonaute protein complexes in organisms from all three kingdoms of life.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PIWI-INTERACTING RNAS; GERMLINE GENE-EXPRESSION; SMALL-INTERFERING RNA; TRANS-ACTING SIRNAS; MICRORNA BIOGENESIS; GUIDE STRAND; CRYSTAL-STRUCTURE; PASSENGER-STRAND; C-ELEGANS; GENOME REARRANGEMENT; Argonaute proteins; gene silencing; microRNAs; RNAi; siRNAs; small RNAs |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Jul 2020 09:59 |
| Last Modified: | 24 Jul 2020 09:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10138 |
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