Krupar, Rosemarie and Hartl, Michael and Wirsching, Kornelia and Dietmaier, Wolfgang and Strutz, Juergen and Hofstaedter, Ferdinand (2014) Comparison of HPV prevalence in HNSCC patients with regard to regional and socioeconomic factors. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 271 (6). pp. 1737-1745. ISSN 0937-4477, 1434-4726
Full text not available from this repository. (Request a copy)Abstract
HPV infection is considered as an independent risk factor for head and neck squamous cell carcinomas (HNSCC). Due to highly variable prevalence results in numerous studies, it is, however, difficult to estimate the relevance of HPV infection as risk factor for a specific patient collective. This study aimed to elucidate the disparities of HPV prevalence by analyzing socioeconomically and regionally different patient collectives. Two age, gender, stage and tumor location matched cohorts of 18 private health insured (PHIP) and 16 statutory health insured patients (SIP) suffering from an oropharyngeal squamous cell carcinoma (OSCC) and treated at a university hospital were screened for p16 overexpression and HPV infection by immunohistochemistry and PCR. In addition 85 HNSCC patients of an otolaryngology private practice (PPP) in a rural area were screened for p16 overexpression and positive cases were tested for HPV infection. HPV prevalence was 72.2 % in the PHIP collective in comparison to 25.0 % (p = 0.015) in the SIP collective with a significantly improved 5-year overall survival (p = 0.003) of the PHIP collective. The total HPV prevalence of PPP group was 7.1 % with the highest infection rate in tonsillar carcinomas (33.3 %) and a larger percentage of female patients in the HPV positive group (p = 0.037). This study shows that variable HPV infection rates in HNSCC can be caused by the selection of particular patient collectives, which suggest taking socioeconomic and regional factors into account for a decision on HPV testing, if it is not performed on a routine basis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS INFECTION; NECK-CANCER; OROPHARYNGEAL CANCER; RISK-FACTOR; HEAD; SURVIVAL; METAANALYSIS; TRENDS; EXPRESSION; Human papillomavirus; Oropharyngeal squamous cell carcinoma; Tonsillar carcinoma; Prevalence; Socioeconomic status; Private practice |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Nov 2019 11:46 |
| Last Modified: | 06 Nov 2019 11:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10141 |
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