Sarubin, Nina and Nothdurfter, Caroline and Schuele, Cornelius and Lieb, Martin and Uhr, Manfred and Born, Christoph and Zimmermann, Ricarda and Buehner, Markus and Konopka, Katharina and Rupprecht, Rainer and Baghai, Thomas C. (2014) The influence of Hatha yoga as an add-on treatment in major depression on hypothalamic-pituitary-adrenal-axis activity: A randomized trial. JOURNAL OF PSYCHIATRIC RESEARCH, 53. pp. 76-83. ISSN 0022-3956, 1879-1379
Full text not available from this repository. (Request a copy)Abstract
Objectives: The impact of Hatha yoga as add-on treatment to quetiapine fumarate extended release (QXR) or escitalopram (ESC) in depressed patients on hypothalamic pituitary adrenal (HPA) axis activity was assessed. Methods: 60 inpatients suffering from major depressive disorder (MDD) according to DSM-IV were randomized for a 5 week treatment with Yoga or not (control group) and with either QXR (300 mg/day) or ESC (10 mg/day). Serial dexamethasone/corticotropin releasing hormone (DEX/CRH) tests were performed to assess HPA axis function. The Hamilton Depression Rating Scale (21-HAMD) was used weekly. Results : A more pronounced down regulation of the HPA axis activity due to yoga could not be detected. The stepwise long term cortisol reduction was seen in both medication groups, irrespectively of yoga add-on treatment. In addition, cortisol improvers in week 1 of therapy (reduction in cortisol peak value within the DEX/CRH test) reached significant greater amelioration of depressive symptoms after 5 weeks. Conclusions: Our results suggest that antidepressant agents down regulate HPA axis function to a greater extent than additional Hatha yoga treatment. Moreover, an early reduction of HPA system hyperactivity after one week of pharmacological treatment seems to raise the possibility of a favorable treatment response. (C) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMBINED DEXAMETHASONE/CRH TEST; ANTIDEPRESSANT EFFICACY; ALTERNATIVE MEDICINE; REMITTED DEPRESSION; TREATMENT RESPONSE; CORTISOL RESPONSE; STRESS; QUETIAPINE; DISORDER; COMPLEMENTARY; Yoga; Depression; Escitalopram; Quetiapine; Cortisol; DEX/CRH-test |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Nov 2019 13:06 |
| Last Modified: | 06 Nov 2019 13:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10149 |
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