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S. and Mueller-Nurasyid, Martina and Navarro, Pau and Perusse, Louis and Pervjakova, Natalia and Sarti, Cinzia and Smith, Albert Vernon and Smith, Jennifer A. and Stancakova, Alena and Strawbridge, Rona J. and Stringham, Heather M. and Sung, Yun Ju and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and van der Laan, Sander W. and van der Most, Peter J. and Van Vliet-Ostaptchouk, Jana V. and Vedantam, Sailaja L. and Verweij, Niek and Vink, Jacqueline M. and Vitart, Veronique and Wu, Ying and Yengo, Loic and Zhang, Weihua and Zhao, Jing Hua and Zimmermann, Martina E. and Zubair, Niha and Abecasis, Goncalo R. and Adair, Linda S. and Afaq, Saima and Afzal, Uzma and Bakker, Stephan J. L. and Bartz, Traci M. and Beilby, John and Bergman, Richard N. and Bergmann, Sven and Biffar, Reiner and Blangero, John and Boerwinkle, Eric and Bonnycastle, Lori L. and Bottinger, Erwin and Braga, Daniele and Buckley, Brendan M. and Buyske, Steve and Campbell, Harry and Chambers, John C. and Collins, Francis S. and Curran, Joanne E. and de Borst, Gert J. and de Craen, Anton J. M. and de Geus, Eco J. C. and Dedoussis, George and Delgado, Graciela E. and den Ruijter, Hester M. and Eiriksdottir, Gudny and Eriksson, Anna L. and Esko, Tonu and Faul, Jessica D. and Ford, Ian and Forrester, Terrence and Gertow, Karl and Gigante, Bruna and Glorioso, Nicola and Gong, Jian and Grallert, Harald and Grammer, Tanja B. and Grarup, Niels and Haitjema, Saskia and Hallmans, Goran and Hamsten, Anders and Hansen, Torben and Harris, Tamara B. and Hartman, Catharina A. and Hassinen, Maija and Hastie, Nicholas D. and Heath, Andrew C. and Hernandez, Dena and Hindorff, Lucia and Hocking, Lynne J. and Hollensted, Mette and Holmen, Oddgeir L. and Homuth, Georg and Hottenga, Jouke Jan and Huang, Jie and Hung, Joseph and Hutri-Kahonen, Nina and Ingelsson, Erik and James, Alan L. and Jansson, John-Olov and Jarvelin, Marjo-Riitta and Jhun, Min A. and Jorgensen, Marit E. and Juonala, Markus and Kahonen, Mika and Karlsson, Magnus and Koistinen, Heikki A. and Kolcic, Ivana and Kolovou, Genovefa and Kooperberg, Charles and Kramer, Bernhard K. and Kuusisto, Johanna and Kvaloy, Kirsti and Lakka, Timo A. and Langenberg, Claudia and Launer, Lenore J. and Leander, Karin and Lee, Nanette R. and Lind, Lars and Lindgren, Cecilia M. and Linneberg, Allan and Lobbens, Stephane and Loh, Marie and Lorentzon, Mattias and Luben, Robert and Lubke, Gitta and Ludolph-Donislawski, Anja and Lupoli, Sara and Madden, Pamela A. F. and Mannikko, Reija and Marques-Vidal, Pedro and Martin, Nicholas G. and McKenzie, Colin A. and McKnight, Barbara and Mellstrom, Dan and Menni, Cristina and Montgomery, Grant W. and Musk, A. W. (Bill) and Narisu, Narisu and Nauck, Matthias and Nolte, Ilja M. and Oldehinkel, Albertine J. and Olden, Matthias and Ong, Ken K. and Padmanabhan, Sandosh and Peyser, Patricia A. and Pisinger, Charlotta and Porteous, David J. and Raitakari, Olli T. and Rankinen, Tuomo and Rao, D. C. and Rasmussen-Torvik, Laura J. and Rawal, Rajesh and Rice, Treva and Ridker, Paul M. and Rose, Lynda M. and Bien, Stephanie A. and Rudan, Igor and Sanna, Serena and Sarzynski, Mark A. and Sattar, Naveed and Savonen, Kai and Schlessinger, David and Scholtens, Salome and Schurmann, Claudia and Scott, Robert A. and Sennblad, Bengt and Siemelink, Marten A. and Silbernagel, Gunther and Slagboom, P. 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R. and Kivimaki, Mika and Kooner, Jaspal S. and Kuh, Diana and Laakso, Markku and Lehtimaki, Terho and Le Marchand, Loic and Marz, Winfried and McCarthy, Mark I. and Metspalu, Andres and Morris, Andrew P. and Ohlsson, Claes and Palmer, Lyle J. and Pasterkamp, Gerard and Pedersen, Oluf and Peters, Annette and Peters, Ulrike and Polasek, Ozren and Psaty, Bruce M. and Qi, Lu and Rauramaa, Rainer and Smith, Blair H. and Sorensen, Thorkild I. A. and Strauch, Konstantin and Tiemeier, Henning and Tremoli, Elena and Van der Harst, Pim and Vestergaard, Henrik and Vollenweider, Peter and Wareham, Nicholas J. and Weir, David R. and Whitfield, John B. and Wilson, James F. and Tyrrell, Jessica and Frayling, Timothy M. and Barroso, Ines and Boehnke, Michael and Deloukas, Panagiotis and Fox, Caroline S. and Hirschhorn, Joel N. and Hunter, David J. and Spector, Tim D. and Strachan, David P. and van Duijn, Cornelia M. and Heid, Iris M. and Mohlke, Karen L. and Marchini, Jonathan and Loos, Ruth J. F. and Kilpelainen, Tuomas O. and Liu, Ching-Ti and Borecki, Ingrid B. and North, Kari E. and Cupples, L. Adrienne (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. NATURE COMMUNICATIONS, 8: 14977. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXIDATIVE STRESS; METABOLIC SYNDROME; VITAMIN-C; ASSOCIATION; GENE; DEFICIENCY; POPULATION; MICE; IMPUTATION; ADDICTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:10 |
| Last Modified: | 25 Feb 2019 13:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1015 |
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