Berking, Carola and Hauschild, Axel and Koelbl, Oliver and Mast, Gerson and Gutzmer, Ralf (2014) Basal Cell Carcinoma-Treatments for the Commonest Skin Cancer. DEUTSCHES ARZTEBLATT INTERNATIONAL, 111 (22). pp. 389-395. ISSN 1866-0452
Full text not available from this repository. (Request a copy)Abstract
Background: With an incidence of 70 to over 800 new cases per 100 000 persons per year, basal cell carcinoma (BCC) is a very common disease, accounting for about 80% of all cases of non-melanoma skin cancer. It very rarely metastasizes. A variety of treatments are available for the different subtypes and stages of BCC. Methods: This review is based on pertinent literature retrieved by a selective search in the Medline database, as well as the American Cancer Society guidelines on BCC and the German guide-lines on BCC and skin cancer prevention. Results: The gold standard of treatment is surgical excision with histological control of excision margins, which has a 5-year recurrence rate of less than 3% on the face. For superficial BCC, approved medications such as imiquimod (total remission rate, 82-90%) and topical 5-fluorouracil (80%) are available, as is photodynamic therapy (71-87%). Other ablative methods (laser, cryosurgery) are applicable in some cases. Radiotherapy is an alternative treatment for invasive, inoperable BCC, with 5-year tumor control rates of 89-96%. Recently, drugs that inhibit an intracellular signaling pathway have become available for the treatment of locally advanced or metastatic BCC. Phase I and II clinical trials revealed that vismodegib was associated with objective response rates of 30-55% and tumor control rates of 80-90%. This drug was approved on the basis of a non-randomized trial with no control arm. It has side effects ranging from muscle cramps (71%) and hair loss (65%) to taste disturbances (55%) and birth defects. Conclusion: The established, standard treatments are generally highly effective. Vismodegib is a newly approved treatment option for locally advanced BCC that is not amenable to either surgery or radiotherapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RANDOMIZED CONTROLLED-TRIAL; AMINOLEVULINATE PHOTODYNAMIC THERAPY; MOHS MICROGRAPHIC SURGERY; SMOOTHENED INHIBITOR; HELICAL TOMOTHERAPY; SURGICAL EXCISION; HEDGEHOG PATHWAY; RISK-FACTORS; OPEN-LABEL; FOLLOW-UP; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Jul 2020 09:55 |
| Last Modified: | 24 Jul 2020 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10151 |
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