Eggenhofer, Elke and Luk, Franka and Dahlke, Marc H. and Hoogduijn, Martin J. (2014) The life and fate of mesenchymal stem cells. FRONTIERS IN IMMUNOLOGY, 5: 148. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
Mesenchymal stem cells (MSC) are present throughout the body and are thought to play a role in tissue regeneration and control of inflammation. MSC can be easily expanded in vitro and their potential as a therapeutic option for degenerative and inflammatory disease is therefore intensively investigated. Whilst it was initially thought that MSC would replace dysfunctional cells and migrate to sites of injury to interact with inflammatory cells, experimental evidence indicates that the majority of administered MSC get trapped in capillary networks and have a short life span. In this review, we discuss current knowledge on the migratory properties of endogenous and exogenous MSC and confer on how culture-induced modifications of MSC may affect these properties. Finally, we will discuss how, despite their limited survival, administered MSC can bring about their therapeutic effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MARROW STROMAL CELLS; ACUTE KIDNEY INJURY; REGULATORY T-CELLS; HUMAN BONE-MARROW; OSTEOGENESIS IMPERFECTA; MYOCARDIAL-INFARCTION; FUNCTIONAL RECOVERY; PERIPHERAL-BLOOD; REPAIR; MIGRATION; mesenchymal stem cells; culture; migration; homing; survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Jul 2020 10:07 |
| Last Modified: | 24 Jul 2020 10:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10176 |
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