Schlotz, Wolff and Godfrey, Keith M. and Phillips, David I. (2014) Prenatal Origins of Temperament: Fetal Growth, Brain Structure, and Inhibitory Control in Adolescence. PLOS ONE, 9 (5): e96715. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Objective: Individual differences in the temperamental dimension of effortful control are constitutionally based and have been associated with an adverse prenatal developmental environment, with structural brain alterations presenting a potential mechanism. We investigated this hypothesis for anatomically defined brain regions implicated in cognitive and inhibitory motor control. Methods: Twenty-seven 15-16 year old participants with low, medium, or high fetal growth were selected from a longitudinal birth cohort to maximize variation and represent the full normal spectrum of fetal growth. Outcome measures were parent ratings of attention and inhibitory control, thickness and surface area of the orbitofrontal cortex (lateral (LOFC) and medial (MOFC)) and right inferior frontal gyrus (rIFG), and volumetric measures of the striatum and amygdala. Results: Lower birth weight was associated with lower inhibitory control, smaller surface area of LOFC, MOFC and rIFG, lower caudate volume, and thicker MOFC. A mediation model found a significant indirect effect of birth weight on inhibitory control via caudate volume. Conclusions: Our findings support a neuroanatomical mechanism underlying potential long-term consequences of an adverse fetal developmental environment for behavioral inhibitory control in adolescence and have implications for understanding putative prenatal developmental origins of externalizing behavioral problems and self-control.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; CHRONIC PLACENTAL INSUFFICIENCY; DEFICIT HYPERACTIVITY DISORDER; EFFORTFUL CONTROL; BIRTH-WEIGHT; RESPONSE-INHIBITION; NEURAL BASIS; COGNITIVE CONTROL; DEVELOPMENTAL PSYCHOPATHOLOGY; EXTERNALIZING PROBLEMS; |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2019 14:47 |
| Last Modified: | 08 Nov 2019 14:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10192 |
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