Schaible, Hans-Georg and Straub, Rainer H. (2014) Function of the sympathetic supply in acute and chronic experimental joint inflammation. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 182. pp. 55-64. ISSN 1566-0702, 1872-7484
Full text not available from this repository.Abstract
Joints are densely innervated by postganglionic sympathetic nerve fibers. These fibers control the blood flow in the joint and vascular permeability, either directly or indirectly, in cooperation with leukocytes. Chemical sympathectomy or suppression of adrenergic signaling significantly reduces inflammatory processes in the initial acute state of inflammation whereas the same procedures may increase inflammation at later stages. These findings indicate that the sympathetic nervous system supports the development of inflammation but may reduce inflammation at more chronic stages. During chronic inflammation the density of sympathetic nerve fibers in synovial tissue is reduced but other tyrosine hydroxylase-positive cells secreting noradrenaline appear in the inflamed joint. In addition to local vascular effects in the joint, the sympathetic nervous system influences numerous immune processes in the joint and in lymphoid organs. Hence the net effect of the sympathetic nervous system on inflamed tissue results from local sympathetic effects in the joint as well as from sympathetic influences on major systemic immune processes. (c) 2013 Published by Elsevier B.V.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLLAGEN-INDUCED ARTHRITIS; ADJUVANT-INDUCED ARTHRITIS; INFLAMED KNEE JOINTS; SYNOVIAL PLASMA EXTRAVASATION; POSTERIOR ARTICULAR NERVES; PEPTIDE-CONTAINING NERVES; COUPLED RECEPTOR KINASES; RHEUMATOID-ARTHRITIS; NERVOUS-SYSTEM; BLOOD-VESSELS; Arthritis; Joint inflammation; Sympathetic joint innervation; Neuroimmune connections |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2019 09:39 |
| Last Modified: | 13 Nov 2019 09:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10244 |
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