Grassinger, Jochen and Khomenko, Andrei and Hart, Christina and Baldaranov, Dobri and Johannesen, Siw W. and Mueller, Gunnar and Schelker, Roland and Schulte-Mattler, Wilhelm and Andreesen, Reinhard and Bogdahn, Ulrich (2014) Safety and feasibility of long term administration of recombinant human granulocyte-colony stimulating factor in patients with amyotrophic lateral sclerosis. CYTOKINE, 67 (1). pp. 21-28. ISSN 1043-4666, 1096-0023
Full text not available from this repository. (Request a copy)Abstract
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neuronal disease resulting in a loss of the upper and lower motor neurons and subsequent death within three to four years after diagnosis. Mouse models and preliminary human exposure data suggest that the treatment with granulocyte-colony stimulating factor (G-CSF) has neuro-protective effects and may delay ALS progression. As data on long-term administration of G-CSF in patients with normal bone marrow (BM) function are scarce, we initiated a compassionate use program including 6 ALS patients with monthly G-CSF treatment cycles. Here we demonstrate that G-CSF injection was safe and feasible throughout our observation period up to three years. Significant decrease of mobilization efficiency occurred in one patient and a loss of immature erythroid progenitors was observed in all six patients. These data imply that follow-up studies analyzing BM function during long-term G-CSF stimulation are required. (C) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMATOPOIETIC PROGENITOR CELLS; G-CSF; PERIPHERAL-BLOOD; BONE-MARROW; STEM-CELLS; HEALTHY DONORS; MESSENGER-RNA; MOUSE MODEL; MOBILIZATION; LEUKEMIA; Amyotrophic lateral sclerosis; ALS; Granulocyte-colony stimulating factor; G-CSF |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2019 09:59 |
| Last Modified: | 13 Nov 2019 09:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10255 |
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