Winkler, Thomas W. and Day, Felix R. and Croteau-Chonka, Damien C. and Wood, Andrew R. and Locke, Adam E. and Maegi, Reedik and Ferreira, Teresa and Fall, Tove and Graff, Mariaelisa and Justice, Anne E. and Luan, Jian'an and Gustafsson, Stefan and Randall, Joshua C. and Vedantam, Sailaja and Workalemahu, Tsegaselassie and Kilpelainen, Tuomas O. and Scherag, Andre and Esko, Tonu and Kutalik, Zoltan and Heid, Iris M. and Loos, Ruth J. F. (2014) Quality control and conduct of genome-wide association meta-analyses. NATURE PROTOCOLS, 9 (5). pp. 1192-1212. ISSN 1754-2189, 1750-2799
Full text not available from this repository. (Request a copy)Abstract
Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta- level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; BIOLOGICAL PATHWAYS; ANALYSES IDENTIFY; GLYCEMIC TRAITS; LOCI; VARIANTS; DISEASE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2019 11:47 |
| Last Modified: | 13 Nov 2019 11:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10270 |
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