Verloh, N. and Haimerl, M. and Zeman, F. and Schlabeck, M. and Barreiros, A. and Loss, M. and Schreyer, A. G. and Stroszczynski, C. and Fellner, C. and Wiggermann, P. (2014) Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla. EUROPEAN RADIOLOGY, 24 (5). pp. 1013-1019. ISSN 0938-7994, 1432-1084
Full text not available from this repository. (Request a copy)Abstract
Objectives The purpose of this study was to evaluate the usefulness of Gd-EOB-DTPA-enhanced 3-T MRI to determine the hepatic functional reserve expressed by the model for end-stage liver disease (MELD) score. Methods A total of 121 patients with normal liver function (NLF; MELD score <= 10) and 29 patients with impaired liver function (ILF; MELD score > 10) underwent contrast-enhanced MRI with a hepatocyte-specific contrast agent at 3T. T1-weighted volume interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 min after contrast injection. Relative enhancement (RE) between plain signal intensity and contrast-enhanced signal intensity was calculated and was used to determine Gd-EOB-DTPA uptake into the liver parenchyma for patients with different MELD scores. Results RE differed significantly (p <= 0.001) between patients with NLF (87.2 +/- 29.5 %) and patients with ILF (45.4 +/- 26.5 %). The optimal cut-off value for RE to differentiate NLF from ILF was 47.7 % (AUC 0.87). This cut-off value showed a sensitivity of 82.8 % and a specificity of 92.7 % for the differentiation of the analysed groups. Conclusion Gd-EOB-DTPA uptake in hepatocytes is strongly affected by liver function. Gd-EOB-DTPA-enhanced MRI and assessment of RE during the hepatobiliary phase (HBP) may serve as a useful image-based test in liver imaging for determining regional and global liver function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORGANIC ANION TRANSPORTERS; PORTAL-VEIN EMBOLIZATION; MAJOR HEPATIC RESECTION; CONTRAST AGENT; GADOXETATE DISODIUM; HEPATOCELLULAR-CARCINOMA; SIGNAL INTENSITY; DISEASE MELD; MODEL; CIRRHOSIS; Magnetic resonance imaging; Gd-EOB-DTPA; Abdomen; Liver; Model for end-stage liver disease ( MELD) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2019 13:51 |
| Last Modified: | 13 Nov 2019 13:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10272 |
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