Nothdurfter, Caroline and Schmotz, Christian and Sarubin, Nina and Baghai, Thomas C. and Laenger, Anna and Lieb, Martin and Bondy, Brigitta and Rupprecht, Rainer and Schuele, Cornelius (2014) Effects of escitalopram/quetiapine combination therapy versus escitalopram monotherapy on hypothalamic-pituitary-adrenal-axis activity in relation to antidepressant effectiveness. JOURNAL OF PSYCHIATRIC RESEARCH, 52. pp. 15-20. ISSN 0022-3956, 1879-1379
Full text not available from this repository. (Request a copy)Abstract
The hypothalamic pituitary adrenocortical (HPA) system is believed to play an important role in the pathophysiology of major depressive disorder. In this context, the atypical antipsychotic quetiapine (QUE) has been shown to inhibit HPA system activity in healthy subjects. In this study we investigated whether the putative inhibitory effects of QUE on HPA system activity may contribute to its antidepressant efficacy. We analyzed the effects of QUE as an augmentation to the selective serotonin reuptake inhibitor (SSRI) escitalopram (ESC) on HPA system activity in comparison to a monotherapy with ESC in relation to the antidepressant effectiveness. HPA axis activity (cortisol and ACTH) was measured by means of the dexamethasone/corticotropin-releasing hormone (DEX/CRH) test which was performed before (week 0) and during (week 1, week 5) antidepressant psychopharmacotherapy. The combination therapy, but not the ESC monotherapy showed significantly inhibiting effects on HPA system activity leading to stepwise down-regulation. ACTH concentrations were reduced in the ESC/QUE group during five weeks of treatment. The inhibitory effect of QUE maybe involved in its antidepressant effects as an augmentation strategy. (C) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAJOR DEPRESSIVE DISORDER; ATYPICAL ANTIPSYCHOTICS; GLUCOCORTICOID-RECEPTOR; ADRENOCORTICAL AXIS; CEREBROSPINAL-FLUID; CORTISOL SECRETION; CLINICAL-RESPONSE; HEALTHY-SUBJECTS; DOUBLE-BLIND; DEX/CRH-TEST; Major depression; Escitalopram; Quetiapine; Hypothalamic-pituitary-adrenal-axis; Cortisol; DEX/CRH test |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2019 14:51 |
| Last Modified: | 13 Nov 2019 14:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10275 |
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