Pollinger, K. and Hennig, R. and Bauer, S. and Breunig, M. and Tessmar, J. and Buschauer, A. and Witzgall, R. and Goepferich, A. (2014) Biodistribution of Quantum Dots in the Kidney After Intravenous Injection. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 14 (5). pp. 3313-3319. ISSN 1533-4880, 1533-4899
Full text not available from this repository.Abstract
The biodistribution of nanoparticles is a major subject of current nanomedical research. To date, however, the exact investigation of nanoparticle fate in the microenvironment of a main excretory organ, the kidney has largely been neglected. In this study, the biodistribution of polyethylene glycol-coated quantum dots (Qdots) with special focus on their interaction with the kidney is investigated. Upon intravenous injection, nanoparticles showed effective blood circulation in mice and significant renal accumulation after two hours. Histological analysis of the kidney revealed that Qdots were strongly associated to the intraglomerular mesangial cells. This preferential deposition of nanoparticles in the kidney mesangium is highly promising, since it could be of utmost value for site-specific treatment of severe kidney diseases like diabetic nephropathy in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELLULAR-DRUG DELIVERY; DIABETIC-NEPHROPATHY; GLOMERULAR-FILTRATION; GOLD NANOPARTICLES; MESANGIAL CELL; SIZE; MECHANISMS; GLOMERULONEPHRITIS; CLEARANCE; SYSTEMS; Nanomedicine; Kidney Targeting; Mesangial Cells; Glomerulus; Quantum Dots |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2019 14:16 |
| Last Modified: | 13 Nov 2019 14:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10279 |
Actions (login required)
 |
View Item |
