Schueler, Susanne and Lattrich, Claus and Skrzypczak, Maciej and Fehm, Tanja and Ortmann, Olaf and Treeck, Oliver (2014) Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer. JOURNAL OF OVARIAN RESEARCH, 7: 42. ISSN 1757-2215,
Full text not available from this repository. (Request a copy)Abstract
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose, we compared the genotype and allele frequencies of the SNPs rs1467465 and rs12048235 in a group of 184 ovarian cancer patients with a control group of 184 age- and gender-matched women without any malignancy. Genotype-phenotype association revealed that A allele of SNP rs1467465 was more frequent in ovarian cancer patients than in the control group (0.40 vs. 0.33, OR 1.37, 95% CI 1.013-1.853, p = 0.04). After analysis of allele positivity we observed that A-positive genotypes were more frequent in the ovarian cancer group (0.65 vs. 0.53, OR 1.63, 95% CI 1.072-2.483, p = 0.02). Furthermore, the heterozygous genotype of rs1467465 was found to be more frequent in the patients group (0.50 vs. 0.41, OR 1.63, 95% CI 1.045-2.045, p = 0.03). No significant results were obtained with regard to SNP rs1204823. Our data suggest, that SNP rs1467465 of human gene icb-1 might affect susceptibility to ovarian cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SINGLE-NUCLEOTIDE POLYMORPHISMS; BREAST-CANCER; CELL-LINES; ESTROGEN; PROMOTER; GROWTH; RISK; EXPRESSION; 1ST-INTRON; PROTEIN; Ovarian cancer; icb-1 gene; Single nucleotide polymorphism; Case control study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Nov 2019 08:58 |
| Last Modified: | 14 Nov 2019 08:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10296 |
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