Aukema, Sietse M. and Kreuz, Markus and Kohler, Christian W. and Rosolowski, Maciej and Hasenclever, Dirk and Hummel, Michael and Kueppers, Ralf and Lenze, Dido and Ott, German and Pott, Christiane and Richter, Julia and Rosenwald, Andreas and Szczepanowski, Monika and Schwaenen, Carsten and Stein, Harald and Trautmann, Heiko and Wessendorf, Swen and Truemper, Lorenz and Loeffler, Markus and Spang, Rainer and Kluin, Philip M. and Klapper, Wolfram and Siebert, Reiner (2014) Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma. HAEMATOLOGICA, 99 (4). pp. 726-735. ISSN 0390-6078,
Full text not available from this repository. (Request a copy)Abstract
Chromosomal translocations affecting the MYC oncogene are the biological hallmark of Burkitt lymphomas but also occur in a subset of other mature B-cell lymphomas. If accompanied by a chromosomal break targeting the BCL2 and/or BCL6 oncogene these MYC translocation-positive (MYC+) lymphomas are called double-hit lymphomas, otherwise the term single-hit lymphomas is applied. In order to characterize the biological features of these MYC+ lymphomas other than Burkitt lymphoma we explored, after exclusion of molecular Burkitt lymphoma as defined by gene expression profiling, the molecular, pathological and clinical aspects of 80 MYC-translocation-positive lymphomas (31 single-hit, 46 double-hit and 3 MYC+-lymphomas with unknown BCL6 status). Comparison of single-hit and double-hit lymphomas revealed no difference in MYC partner (IG/non-IG), genomic complexity, MYC expression or gene expression profile. Double-hit lymphomas more frequently showed a germinal center B-cell-like gene expression profile and had higher IGH and MYC mutation frequencies. Gene expression profiling revealed 130 differentially expressed genes between BCL6(+)/MYC+ and BCL2(+)/MYC+ double-hit lymphomas. BCL2(+)/MYC+ double-hit lymphomas more frequently showed a germinal center B-like gene expression profile. Analysis of all lymphomas according to MYC partner (IG/non-IG) revealed no substantial differences. In this series of lymphomas, in which immunochemotherapy was administered in only a minority of cases, single-hit and double-hit lymphomas had a similar poor outcome in contrast to the outcome of molecular Burkitt lymphoma and lymphomas without the MYC break. Our data suggest that, after excluding molecular Burkitt lymphoma and pediatric cases, MYC+ lymphomas are biologically quite homogeneous with single-hit and double-hit lymphomas as well as IG-MYC and non-IG-MYC+ lymphomas sharing various molecular characteristics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RITUXIMAB PLUS CYCLOPHOSPHAMIDE; C-MYC; GENE-EXPRESSION; GENOMIC ABERRATIONS; FOLLICULAR LYMPHOMA; PROGNOSTIC-FACTOR; POOR-PROGNOSIS; GRADE 3B; DISTINCT; REARRANGEMENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Nov 2019 14:46 |
| Last Modified: | 14 Nov 2019 14:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10348 |
Actions (login required)
 |
View Item |
