Agha, Ayman and Benseler, Volker and Hornung, Matthias and Gerken, Michael and Iesalnieks, Igors and Fuerst, Alois and Anthuber, Matthias and Jauch, Karl-Walter and Schlitt, Hans J. (2014) Long-term oncologic outcome after laparoscopic surgery for rectal cancer. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 28 (4). pp. 1119-1125. ISSN 0930-2794, 1432-2218
Full text not available from this repository. (Request a copy)Abstract
Recent studies demonstrated favorable short- and mid-term results after laparoscopic surgery for rectal cancer. However, long-term results from large series are lacking. The present study analyses long-term results of laparoscopic rectal cancer surgery from a large-volume center. From January 1998 until March 2005, 225 patients underwent laparoscopic rectal resection due to carcinoma at the Medical Centre of the University of Regensburg. From 224 patients, a follow-up over 10 years was performed using the data of the Tumour Centre of the University of Regensburg. The data were analysed using oncological data (tumour recurrence) as well as overall survival. In addition, the effect of conversion to open resection on overall survival was analysed. With a median of 10 years at follow-up, the overall and disease-free survival was 50.5 and 50.1 %, respectively. Local recurrence of all patients was 5.8 % and none of the converted patients was within this group. The median time interval for the development of local recurrence was 30 months. Six of the 13 patients with local recurrence (46.1 %) had received neoadjuvant radiochemotherapy before surgery. Patients with a conversion to open surgery had primarily a significantly worse outcome than patients resected completely laparoscopically (p = 0.003). However, this difference was no longer apparent using a multivariant analysis (hazard ratio 1.221; p = 0.478). Overall survival and local recurrence rate of patients undergoing laparoscopic resection of rectal cancer are comparable to open surgery. However, in our analysis, patients undergoing laparoscopic anterior resection had a higher survival rate compared with patients with abdominoperineal resection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COUNCIL CLASICC TRIAL; COLORECTAL-CANCER; FOLLOW-UP; POSTOPERATIVE CHEMORADIOTHERAPY; RESECTION; MULTICENTER; MORBIDITY; IMPACT; Laparoscopic rectal surgery; Conversion; Rectal cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2019 09:18 |
| Last Modified: | 15 Nov 2019 09:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10377 |
Actions (login required)
 |
View Item |
