Berner, A. and Woodruff, M. A. and Lam, C. X. F. and Arafat, M. T. and Saifzadeh, S. and Steck, R. and Ren, J. and Nerlich, M. and Ekaputra, A. K. and Gibson, I. and Hutmacher, D. W. (2014) Effects of scaffold architecture on cranial bone healing. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43 (4). pp. 506-513. ISSN 0901-5027, 1399-0020
Full text not available from this repository. (Request a copy)Abstract
In the present study, polycaprolactone tricalcium phosphate (PCL/TCP) scaffolds with two different fibre laydown patterns, which were coated with hydroxyapatite and gelatine, were used as an approach for optimizing bone regeneration in a critical-sized calvarial defect. After 12 weeks, bone regeneration was quantified using microcomputed tomography (micro-CT) analysis, biomechanical testing, and histological evaluation. Notably, the experimental groups with coated scaffolds showed lower bone formation and lower biomechanical properties within the defect compared to the uncoated scaffolds. Surprisingly, the different laydown pattern of the fibres resulted in different bone formation and biomechanical properties: the 0 degrees/60 degrees/12 degrees scaffolds revealed lower bone formation and biomechanical properties compared to the 0 degrees/90 degrees scaffolds in all the experimental groups. Therefore, future bone regeneration strategies utilizing scaffolds should consider scaffold architecture as an important factor during the scaffold optimization stages in order to move closer to a clinical application.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DYNAMIC-MECHANICAL PROPERTIES; TISSUE; MODEL; POLYCAPROLACTONE; MINERALIZATION; POROSITY; SIZE; bone tissue engineering; scaffolds; polycaprolactone; laydown pattern; rat skull defect |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2019 10:32 |
| Last Modified: | 15 Nov 2019 10:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10404 |
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