Gierth, M. and Fritsche, H. M. and Buchner, H. and May, M. and Aziz, A. and Otto, W. and Bolenz, C. and Trojan, L. and Hermann, E. and Tiemann, A. and Mueller, S. C. and Ellinger, J. and Brookman-May, S. and Stief, C. G. and Tilki, D. and Nuhn, P. and Hoefner, T. and Hohenfellner, M. and Haferkamp, A. and Roigas, J. and Zacharias, M. and Wieland, W. F. and Riedmiller, H. and Denzinger, S. and Bastian, P. J. and Burger, M. (2014) Clinical and pathological nodal staging score for urothelial carcinoma of the bladder: an external validation. WORLD JOURNAL OF UROLOGY, 32 (2). pp. 365-371. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
Radical cystectomy (RC) and pelvic lymph node dissection (LND) are standard treatments for muscle-invasive urothelial carcinoma of the bladder. Lymph node staging is a prerequisite for clinical decision-making regarding adjuvant chemotherapy and follow-up regimens. Recently, the clinical and pathological nodal staging scores (cNSS and pNSS) were developed. Prior to RC, cNSS determines the minimum number of lymph nodes required to be dissected; pNSS quantifies the accuracy of negative nodal staging based on pT stage and dissected LNs. cNSS and pNSS have not been externally validated, and their relevance for prediction of cancer-specific mortality (CSM) has not been assessed. In this retrospective study of 2,483 RC patients from eight German centers, we externally validated cNSS and pNSS and determined their prediction of CSM. All patients underwent RC and LND. Median follow-up was 44 months. cNSS and pNSS sensitivities were evaluated using the original beta-binominal models. Adjusted proportional hazards models were calculated for pN0 patients to assess the predictive value of cNSS and pNSS for CSM. cNSS and pNSS both pass external validation. Adjusted for other clinical parameters, cNSS can predict outcome after RC. pNSS has no independent impact on prediction of CSM. The retrospective design is the major limitation of the study. In the present external validation, we confirm the validity of both cNSS and pNSS. cNSS is an independent predictor of CSM, thus rendering it useful as a tool for planning the extent of LND.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTENDED PELVIC LYMPHADENECTOMY; RADICAL CYSTECTOMY; LYMPH-NODES; PROSTATE-CANCER; MINIMUM NUMBER; EAU GUIDELINES; DISSECTION; NOMOGRAMS; EPIDEMIOLOGY; VARIABILITY; Bladder cancer; Radical cystectomy; Lymph node metastasis; Clinical nodal staging score; Pathological nodal staging score |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2019 11:34 |
| Last Modified: | 15 Nov 2019 11:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10413 |
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