Wanitchakool, Podchanart and Wolf, Luisa and Koehl, Gudrun E. and Sirianant, Lalida and Schreiber, Rainer and Kulkarni, Sucheta and Duvvuri, Umamaheswar and Kunzelmann, Karl (2014) Role of anoctamins in cancer and apoptosis. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369 (1638): 20130096. ISSN 0962-8436, 1471-2970
Full text not available from this repository. (Request a copy)Abstract
Anoctamin 1 (TMEM16A, Ano1) is a recently identified Ca2+-activated chloride channel and a member of a large protein family comprising 10 paralogues. Before Ano1 was identified as a chloride channel protein, it was known as the cancer marker DOG1. DOG1/Ano1 is expressed in gastrointestinal stromal tumours (GIST) and particularly in head and neck squamous cell carcinoma, at very high levels never detected in other tissues. It is now emerging that Ano1 is part of the 11q13 locus, amplified in several types of tumour, where it is thought to augment cell proliferation, cell migration and metastasis. Notably, Ano1 is upregulated through histone deacetylase (HDAC), corresponding to the known role of HDAC in HNSCC. As Ano1 does not enhance proliferation in every cell type, its function is perhaps modulated by cell-specific factors, or by the abundance of other anoctamins. Thus Ano6, by regulating Ca2+-induced membrane phospholipid scrambling and annexin V binding, supports cellular apoptosis rather than proliferation. Current findings implicate other cellular functions of anoctamins, apart from their role as Ca2+-activated Cl- channels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CA2+-ACTIVATED CL-CHANNEL; ION CHANNELS; MEMBRANE-PROTEIN; TRANSCRIPTOME ANALYSIS; INTERSTITIAL-CELLS; TUMOR-CELLS; EXPRESSION; TMEM16A; BREAST; VOLUME; anoctamin 1; anoctamin 6; TMEM16A; TMEM16F; cancer; head and neck stromal cell carcinoma |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Jul 2020 05:31 |
| Last Modified: | 24 Jul 2020 05:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10460 |
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