Dozio, Elena and Malavazos, Alexis Elias and Vianello, Elena and Briganti, Silvia and Dogliotti, Giada and Bandera, Francesco and Giacomazzi, Francesca and Castelvecchio, Serenella and Menicanti, Lorenzo and Sigrueener, Alexander and Schmitz, Gerd and Romanelli, Massimiliano Marco Corsi (2014) Interleukin-15 and Soluble Interleukin-15 Receptor alpha in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution. PLOS ONE, 9 (3): e90960. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via a specific alpha receptor subunit (IL-15R alpha). Increased IL-15 level has been observed in cardiovascular patients and IL-15 immunoreactivity has been detected at vulnerable atherosclerotic plaques. Due to the association between adipose tissue distribution, inflammation and coronary artery disease (CAD), we quantified IL-15 and IL-15R alpha in CAD patients with different adiposity and adipose tissue distribution and we evaluated whether epicardial adipose tissue (EAT), a visceral fat depot surrounding and infiltrating myocardium, may be a source of both molecules. IL-15 and IL-15R alpha proteins were quantified by enzyme-linked immunosorbent assays. Gene expression of IL-15 and IL-15R alpha in EAT depots was evaluated by one colour microarray platform. EAT thickness was measured by echocardiography. Plasmatic IL-15 and IL-15R alpha levels were higher in CAD than non-CAD patients. After classification according to adipose tissue distribution, IL-15 was higher in CAD patients with increased abdominal adiposity. Increased level of IL-15R alpha was observed both in CAD and non-CAD patients with increased abdominal fat. EAT was a source of IL-15 and IL-15R alpha and their expression was higher in CAD patients with increased EAT thickness. In conclusion, our data suggest that circulating levels of IL-15 and IL-15R alpha seem to reflect visceral distribution of adipose tissue and that EAT may be a potential source of both IL-15 and IL-15R alpha. Future studies on the relationship between IL-15, visceral fat and characteristics of atherosclerotic plaques could help to better understand the complex biology of this cytokine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOVASCULAR-DISEASE; CARDIAC ABNORMALITIES; OBESITY; IL-15; ATHEROSCLEROSIS; IL-15R-ALPHA; EXPRESSION; CHAIN; CELL; PATHWAY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Nov 2019 09:19 |
| Last Modified: | 18 Nov 2019 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10479 |
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