Ljubimova, Julia Y. and Sun, Tao and Mashouf, Leila and Ljubimov, Alexander V. and Israel, Liron L. and Ljubimov, Vladimir A. and Falahatian, Vida and Holler, Eggehard (2017) Covalent nano delivery systems for selective imaging and treatment of brain tumors. ADVANCED DRUG DELIVERY REVIEWS, 113. pp. 177-200. ISSN 0169-409X, 1872-8294
Full text not available from this repository. (Request a copy)Abstract
Nanomedicine is a rapidly evolving form of therapy that holds a great promise for superior drug delivery efficiency and therapeutic efficacy than conventional cancer treatment. In this review, we attempt to cover the benefits and the limitations of current nanomedicines with special attention to covalent nano conjugates for imaging and drug delivery in the brain. The improvement in brain tumor treatment remains dismal despite decades of efforts in drug development and patient care. One of the major obstacles in brain cancer treatment is the poor drug delivery efficiency owing to the unique blood-brain barrier (BBB) in the CNS. Although various anti-cancer agents are available to treat tumors outside of the CNS, the majority fails to cross the BBB. In this regard, nanomedicines have increasingly drawn attention due to their multi-functionality and versatility. Nano drugs can penetrate BBB and other biological barriers, and selectively accumulate in tumor cells, while concurrently decreasing systemic toxicity. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-PENETRATING PEPTIDES; CENTRAL-NERVOUS-SYSTEM; POLYPLEX-TRANSFECTION REAGENTS; CHAIN TRANSFER POLYMERIZATION; HPMA-OLIGOLYSINE COPOLYMERS; IRON-OXIDE NANOPARTICLES; BREAST-CANCER-TREATMENT; TARGETED DRUG-DELIVERY; IN-VIVO; POLYMALIC ACID; Covalent nano conjugates; Blood-brain-barrier (BBB); Nanomedicine for brain imaging; Drug delivery; Brain cancer |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 17 Sep 2020 07:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1061 |
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