Stroebel, Philipp and Hartmann, Elena and Rosenwald, Andreas and Kalla, Joerg and Ott, German and Friedel, Godehard and Schalke, Berthold and Kasahara, Masanori and Tomaru, Utano and Marx, Alexander (2014) Corticomedullary differentiation and maturational arrest in thymomas. HISTOPATHOLOGY, 64 (4). pp. 557-566. ISSN 0309-0167, 1365-2559
Full text not available from this repository. (Request a copy)Abstract
AimsMorphological complexity hampers the histological classification of thymomas. Our aim was to determine whether the use of novel differentiation and maturation markers of cortical and medullary thymic epithelial cells (cTECs and mTECs) might provide an approach to understanding the underlying biology of these tumours. Methods and resultsFifty-seven thymomas were studied by immunohistochemistry. The cortical markers used were B5T, PRSS16, and cathepsin V. The medullary markers used were CD40, claudin-4, AIRE, and desmin. Involucrin and cytokeratin 10 were used to study terminal mTEC maturation. Irrespective of histological subtype, most thymomas contained distinct areas with cortical and medullary differentiation. Type B1, type B2 and type AB thymomas showed marked bi-lineage differentiation, with lack of terminal mTEC maturation in type AB. Type AB thymomas were unique in showing areas where cells with either cortical or medullary differentiation were intimately mixed' at the single-cell level. Type B3 and type A thymomas showed only abortive lineage differentiation and maturation. ConclusionsThymomas show highly characteristic patterns of bi-lineage TEC differentiation that reflect the histological subtypes recognized by the WHO classification. We hypothesize that thymomas arise from thymic precursor cells with different cortical and/or medullary maturation defects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THYMIC EPITHELIAL-CELLS; PROTEASOME SUBUNIT BETA-5T; MYASTHENIA-GRAVIS; AUTOIMMUNE REGULATOR; MEDULLARY DIFFERENTIATION; GENETIC ABERRATIONS; POSITIVE SELECTION; SELF-TOLERANCE; CATHEPSIN-V; T-CELLS; classification; cortex; differentiation; medulla; stem cell; thymoma; thymus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Nov 2019 14:39 |
| Last Modified: | 18 Nov 2019 14:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10624 |
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