Salaverria, Itziar and Martin-Guerrero, Idoia and Wagener, Rabea and Kreuz, Markus and Kohler, Christian W. and Richter, Julia and Pienkowska-Grela, Barbara and Adam, Patrick and Burkhardt, Birgit and Claviez, Alexander and Damm-Welk, Christine and Drexler, Hans G. and Hummel, Michael and Jaffe, Elaine S. and Kueppers, Ralf and Lefebvre, Christine and Lisfeld, Jasmin and Loeffler, Markus and Macleod, Roderick A. F. and Nagel, Inga and Oschlies, Ilske and Rosolowski, Maciej and Russell, Robert B. and Rymkiewicz, Grzegorz and Schindler, Detlev and Schlesner, Matthias and Scholtysik, Rene and Schwaenen, Carsten and Spang, Rainer and Szczepanowski, Monika and Truemper, Lorenz and Vater, Inga and Wessendorf, Swen and Klapper, Wolfram and Siebert, Reiner (2014) A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. BLOOD, 123 (8). pp. 1187-1198. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 11q23.2-q23.3 and telomeric losses of 11q24.1-qter. We extended our analysis to 17 MYC-negative high-grade B-cell lymphomas with a similar 11q aberration and showed this aberration to be recurrently associated with morphologic and clinical features of BL. The minimal region of gain was defined by high-level amplifications in 11q23.3 and associated with overexpression of genes including PAFAH1B2 on a transcriptional and protein level. The recurrent region of loss contained a focal homozygous deletion in 11q24.2-q24.3 including the ETS1 gene, which was shown to be mutated in 4 of 16 investigated cases. These findings indicate the existence of a molecularly distinct subset of B-cell lymphomas reminiscent of BL, which is characterized by deregulation of genes in 11q.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKINS-LYMPHOMA; FOLLICULAR LYMPHOMAS; TUMOR-SUPPRESSOR; GENE; MUTATIONS; GENOME; HYBRIDIZATION; ABNORMALITIES; DEREGULATION; PATHOGENESIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Nov 2019 14:43 |
| Last Modified: | 26 Nov 2019 14:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10656 |
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