Dueck, Anne and Eichner, Alexander and Sixt, Michael and Meister, Gunter (2014) A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage activation. FEBS LETTERS, 588 (4). pp. 632-640. ISSN 0014-5793, 1873-3468
Full text not available from this repository. (Request a copy)Abstract
MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in many cellular pathways. MiRNAs associate with members of the Argonaute protein family and bind to partially complementary sequences on mRNAs and induce translational repression or mRNA decay. Using deep sequencing and Northern blotting, we characterized miRNA expression in wild type and miR-155-deficient dendritic cells (DCs) and macrophages. Analysis of different stimuli (LPS, LDL, eLDL, oxLDL) reveals a direct influence of miR-155 on the expression levels of other miRNAs. For example, miR-455 is negatively regulated in miR-155-deficient cells possibly due to inhibition of the transcription factor C/EBPbeta by miR-155. Based on our comprehensive data sets, we propose a model of hierarchical miRNA expression dominated by miR-155 in DCs and macrophages. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARGONAUTE PROTEINS; INFLAMMATION; BIOGENESIS; MIR-155; CANCER; ATHEROSCLEROSIS; INFECTION; RESPONSES; TARGET; MicroRNA; MiR-155; MiR-455; Regulation of gene expression; Dendritic cell; Macrophage |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Nov 2019 15:02 |
| Last Modified: | 26 Nov 2019 15:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10673 |
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