Melnik, Bodo C. and John, Swen Malte and Schmitz, Gerd (2014) Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? JOURNAL OF TRANSLATIONAL MEDICINE, 12: 43. ISSN 1479-5876
Full text not available from this repository. (Request a copy)Abstract
Epidemiological evidence confirmed that raw cow's milk consumption in the first year of life protects against the development of atopic diseases and increases the number of regulatory T-cells (Tregs). However, milk's atopy-protective mode of action remains elusive. This review supported by translational research proposes that milk-derived microRNAs (miRs) may represent the missing candidates that promote long-term lineage commitment of Tregs downregulating IL-4/Th2-mediated atopic sensitization and effector immune responses. Milk transfers exosomal miRs including the ancient miR-155, which is important for the development of the immune system and controls pivotal target genes involved in the regulation of FoxP3 expression, IL-4 signaling, immunoglobulin class switching to IgE and Fc epsilon RI expression. Boiling of milk abolishes milk's exosomal miR-mediated bioactivity. Infant formula in comparison to human breast- or cow's milk is deficient in bioactive exosomal miRs that may impair FoxP3 expression. The boost of milk-mediated miR may induce pivotal immunoregulatory and epigenetic modifications required for long-term thymic Treg lineage commitment explaining the atopy-protective effect of raw cow's milk consumption. The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRIPTION FACTOR FOXP3; IMMUNE-RELATED MICRORNAS; ALDRICH-SYNDROME PROTEIN; DNA METHYLTRANSFERASE 1; NF-KAPPA-B; ALLERGIC DISEASE; INTERCELLULAR COMMUNICATION; CHILDHOOD ASTHMA; BREAST-MILK; EXTRACELLULAR VESICLES; Atopy prevention; DNA demethylation; Exosome; FoxP3; MicroRNA; Milk; MiR-155; Regulatory T cell |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Jul 2020 10:15 |
| Last Modified: | 21 Jul 2020 10:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10674 |
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