Lehle, Karla and Li, Jing and Zimmermann, Hanngoerg and Hartmann, Bjoern and Wehner, Daniel and Schmid, Thomas and Schmid, Christof (2014) In vitro Endothelialization and Platelet Adhesion on Titaniferous Upgraded Polyether and Polycarbonate Polyurethanes. MATERIALS, 7 (2). pp. 623-636. ISSN 1996-1944,
Full text not available from this repository. (Request a copy)Abstract
Polycarbonateurethanes (PCU) and polyetherurethanes (PEU) are used for medical devices, however their bio- and haemocompatibility is limited. In this study, the effect of titaniferous upgrading of different polyurethanes on the bio-and haemocompatibility was investigated by endothelial cell (EC) adhesion/proliferation and platelet adhesion (scanning electron microscopy), respectively. There was no EC adhesion/proliferation and only minor platelet adhesion on upgraded and pure PCU (Desmopan). PEUs (Texin 985, Tecothane 1085, Elastollan 1180A) differed in their cyto-and haemocompatibility. While EC adhesion depended on the type of PEU, any proliferative activity was inhibited. Additional titaniferous upgrading of PEU induced EC proliferation and increased metabolic activity. However, adherent ECs were significantly activated. While Texin was highly thrombotic, only small amounts of platelets adhered onto Tecothane and Elastollan. Additional titaniferous upgrading reduced thrombogenicity of Texin, preserved haemocompatibility of Elastollan, and increased platelet activation/aggregation on Tecothane. In conclusion, none of the PUs was cytocompatible; only titaniferous upgrading allowed EC proliferation and metabolism on PEUs. Haemocompatibility depended on the type of PU.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HARD-SEGMENT CHEMISTRY; HUMAN VASCULAR CELLS; TITANIUM; BIOCOMPATIBILITY; STABILITY; STRESS; TITANIUMCARBOXONITRIDE; BIOMATERIALS; EXPRESSION; RESISTANCE; endothelial cell seeding; cytocompatibility; haemocompatibility; platelet adhesion; cardiovascular tissue engineering; titanium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Nov 2019 10:32 |
| Last Modified: | 27 Nov 2019 10:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10695 |
Actions (login required)
 |
View Item |
