Bundscherer, Anika C. and Malsy, Manuela and Bitzinger, Diane I. and Wiese, Christoph H. R. and Gruber, Michael A. and Graf, Bernhard M. (2017) Effects of Lidocaine on HT-29 and SW480 Colon Cancer Cells In Vitro. ANTICANCER RESEARCH, 37 (4). pp. 1941-1945. ISSN 0250-7005, 1791-7530
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Background: Evidence is growing that the risk of cancer dissemination may be enhanced during the perioperative period. Whether particular anesthetic techniques influence oncological outcome is still under discussion. For pain management, lidocaine can be administered perioperatively by intravenous, intraperitoneal or epidural infusion. Here we investigated the effect of lidocaine on colon carcinoma cell lines (HT-29 and SW480) in vitro. Materials and Methods: ELISA BrdU (Roche) for cell proliferation and FITC Annexin V detection kit (BD Pharming) for apoptosis analysis were applied. Cell-cycle profiles were investigated by flow cytometry. Results: Cell-cycle arrest was induced in both cell lines by 1000 mu M lidocaine, while no inhibition of cell proliferation was detected. Apoptosis decreased in SW480 but not in HT-29 cells. Conclusion: Lidocaine induces cell-cycle arrest in both colon carcinoma cell lines in vitro. The effective drug concentration can be obtained by local infiltration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANESTHETIC TECHNIQUE; RETROSPECTIVE ANALYSIS; EPIDURAL-ANESTHESIA; LOCAL-ANESTHETICS; SURGERY; RECURRENCE; APOPTOSIS; ANALGESIA; ROPIVACAINE; RECOVERY; Lidocaine; local anesthetics; cell proliferation; apoptosis; cell cycle |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 28 Feb 2019 13:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1073 |
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