Stift, Judith and Baba, Hideo A. and Huber, Elisabeth and Federmann, Birgit and Fischer, Hans-Peter and Schmitt-Graeff, Annette and Baurmann, Herrad and Bethge, Wolfgang and Schirmacher, Peter and Wrba, Fritz and Greinix, Hildegard and Fend, Falko and Schwerdtfeger, Rainer and Shulman, Howard M. and Wolff, Daniel and Longerich, Thomas (2014) Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation. VIRCHOWS ARCHIV, 464 (2). pp. 175-190. ISSN 0945-6317, 1432-2307
Full text not available from this repository. (Request a copy)Abstract
After allogeneic hematopoietic cell transplantation (alloHCT) liver biopsy is performed for enigmatic liver disorders when noninvasive diagnostic steps have failed in establishing a definitive diagnosis. This document provides an updated consensus on the prerequisites for proper evaluation of liver biopsies in alloHCT patients and the histological diagnostic criteria for liver graft-versus-host disease (GvHD). The Working Group's recommendations for the histological diagnosis of liver GvHD were derived from the peer-reviewed literature and from the consensus diagnosis of a total of 30 coded liver biopsies. Acceptance of the recommendations was tested by a survey distributed to all HCT centers in Austria, Germany and Switzerland. Consensus was achieved for biopsy indications, methods of sample acquisition and processing, reporting and interpretation of biopsy findings. As GvHD is variably treated and the treatment modalities have changed over time, the panel endorses the use of more frequent biopsies in clinical studies in order to improve the present challenging clinical and diagnostic situation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; DONOR LYMPHOCYTE INFUSION; HEPATIC GRAFT; HEMATOLOGIC MALIGNANCIES; ACUTE GVHD; DIAGNOSIS; COMPLICATIONS; DYSFUNCTION; MORTALITY; Liver; GvHD; Biopsy; Consensus |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Nov 2019 08:55 |
| Last Modified: | 28 Nov 2019 08:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10736 |
Actions (login required)
 |
View Item |
