Lukas, Karin and Stadtherr, Karin and Gessner, Andre and Wehner, Daniel and Schmid, Thomas and Wendel, Hans Peter and Schmid, Christof and Lehle, Karla (2017) Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane. MATERIALS, 10 (4): 335. ISSN 1996-1944,
Full text not available from this repository. (Request a copy)Abstract
The surface of foils and vascular grafts made from a thermoplastic polycarbonate urethanes (PCU) (Chronoflex AR) were chemically modified using gas plasma treatment, binding of hydrogels-(1) polyethylene glycol bisdiamine and carboxymethyl dextran (PEG-DEX) and (2) polyethyleneimine (PEI)-and immobilization of human antithrombin III (AT). Their biological impact was tested in vitro under static and dynamic conditions. Static test methods showed a significantly reduced adhesion of endothelial cells, platelets, and bacteria, compared to untreated PCU. Modified PCU grafts were circulated in a Chandler-Loop model for 90 min at 37 degrees C with human blood. Before and after circulation, parameters of the hemostatic system (coagulation, platelets, complement, and leukocyte activation) were analyzed. PEI-AT significantly inhibited the activation of both coagulation and platelets and prevented the activation of leukocytes and complement. In conclusion, both modifications significantly reduce coagulation activation, but only PEI-AT creates anti-bacterial and anti-thrombogenic functionality.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VENTRICULAR ASSIST DEVICES; IN-VITRO; THROMBIN INHIBITOR; EXTRACORPOREAL-CIRCULATION; ENGINEERING APPLICATIONS; BLOOD COMPATIBILITY; PLATELET-ADHESION; NITRIC-OXIDE; ISO 10993-4; HEMOCOMPATIBILITY; polycarbonate urethane; thromboresistance; antithrombin III; anti-bacterial; hemocomaptibility |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 28 Feb 2019 10:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1074 |
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